Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 535172, 11 pages
http://dx.doi.org/10.1093/ecam/nep180
Original Article

Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells

1Chair and Department of Microbiology and Immunology, Jordana 19, 41808 Zabrze, Poland
2Chair and Department of Urology, 3-go Maja 13, 41 800 Zabrze, Medical University of Silesia in Katowice, Poland

Received 28 February 2009; Accepted 6 October 2009

Copyright © 2011 Ewelina Szliszka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Heidenreich, G. Aus, M. Bolla et al., “EAU guidelines on prostate cancer,” European Urology, vol. 53, no. 1, pp. 68–80, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. R. P. Singh and R. Agarwal, “Mechanisms of action of novel agents for prostate cancer chemoprevention,” Endocrine-Related Cancer, vol. 13, no. 3, pp. 751–778, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. D. N. Syed, Y. Suh, F. Afaq, and H. Mukhtar, “Dietary agents for chemoprevention of prostate cancer,” Cancer Letters, vol. 265, no. 2, pp. 167–176, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. E. L. Cooper, “The immune system and complementary and alternative medicine,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 1, pp. 5–8, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Salvioli, E. Sikora, E. L. Cooper, and C. Franceschi, “Curcumin in cell death processes: a challenge for CAM of age-related pathologies,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 2, pp. 181–190, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Vojdani and J. Erde, “Regulatory T cells, a potent immunoregulatory target for CAM researchers: modulating allergic and infectious disease pathology (II),” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 2, pp. 209–215, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Gardana, M. Scaglianti, P. Pietta, and P. Simonetti, “Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography-tandem mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 45, no. 3, pp. 390–399, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. V. S. Bankova, S. S. Popov, and N. L. Marekov, “A study on flavonoids of propolis,” Journal of Natural Products, vol. 46, no. 4, pp. 471–474, 1983. View at Google Scholar · View at Scopus
  9. W. Krol, S. Scheller, Z. Czuba et al., “Inhibition of neutrophils' chemiluminescence by ethanol extract of propolis (EEP) and its phenolic components,” Journal of Ethnopharmacology, vol. 55, no. 1, pp. 19–25, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Oršolić, A. B. Šaranović, and I. Bašić, “Direct and indirect mechanism(s) of antitumour activity of propolis and its polyphenolic compounds,” Planta Medica, vol. 72, no. 1, pp. 20–27, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Scheller, W. Krol, J. Swiacik, S. Owczarek, J. Gabrys, and J. Shani, “Antitumoral property of ethanolic extract of propolis in mice-bearing Ehrlich carcinoma, as compared to bleomycin,” Zeitschrift für Naturforschung C, vol. 44, no. 11-12, pp. 1063–1065, 1989. View at Google Scholar · View at Scopus
  12. D. F. Birt, S. Hendrich, and W. Wang, “Dietary agents in cancer prevention: flavonoids and isoflavonoids,” Pharmacology and Therapeutics, vol. 90, no. 2-3, pp. 157–177, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Chen, M. Weng, C. Wu, and J. Lin, “Comparison of radical scavenging activity, cytotoxic effects and apoptosis induction in human melanoma cells by Taiwanese propolis from different sources,” Evidence-Based Complementary and Alternative Medicine, vol. 1, pp. 175–185, 2004. View at Google Scholar
  14. M. C. Bufalo, J. M. Candeias, and J. M. Sforcin, “In vitro cytotoxic effect of Brazilian green propolis on human laryngeal epidermoid carcinoma (HEP-2) cells,” Evidence-Based Complementary and Alternative Medicine, vol. 22, pp. 1–5, 2007. View at Google Scholar
  15. F. Missima and J. M. Sforcin, “Green Brazilian propolis action on macrophages and lymphoid organs of chronically stressed mice,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 1, pp. 71–75, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Almasan and A. Ashkenazi, “Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy,” Cytokine and Growth Factor Reviews, vol. 14, no. 3-4, pp. 337–348, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Shankar, T. R. Singh, and R. K. Srivastava, “Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: intracellular mechanisms,” Prostate, vol. 61, no. 1, pp. 35–49, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Horinaka, T. Yoshida, T. Shiraishi, S. Nakata, M. Wakada, and T. Sakai, “The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand,” Molecular Cancer Therapeutics, vol. 5, no. 4, pp. 945–951, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Szliszka, J. Bronikowska, A. Majcher, J. Miszkiewicz, and W. Krol, “Enhanced sensitivity of hormone-refractory prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated cytotoxicity by taxanes,” Central European Journal of Urology, vol. 62, pp. 29–34, 2009. View at Google Scholar
  20. E. Szliszka, Z. P. Czuba, M. Domino, B. Mazur, G. Zydowicz, and W. Krol, “Ethanolic extract of propolis (EEP) enhances the apoptosis-inducing potential of TRAIL in cancer cells,” Molecules, vol. 14, no. 2, pp. 738–754, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Khan, V. M. Adhami, and H. Mukhtar, “Apoptosis by dietary agents for prevention and treatment of cancer,” Biochemical Pharmacology, vol. 76, no. 11, pp. 1333–1339, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Li, A. Kapur, J. X. Yang et al., “Antiproliferation of human prostate cancer cells by ethanolic extracts of Brazilian propolis and its botanical origin,” International Journal of Oncology, vol. 31, no. 3, pp. 601–606, 2007. View at Google Scholar · View at Scopus
  23. S. Shukla and S. Gupta, “Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft,” Molecular Cancer Therapeutics, vol. 5, no. 4, pp. 843–852, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. K. McEleny, R. Coffey, C. Morrissey, J. M. Fitzpatrick, and R. W. G. Watson, “Caffeic acid phenethyl ester-induced PC-3 cell apoptosis is caspase-dependent and mediated through the loss of inhibitors of apoptosis proteins,” BJU International, vol. 94, no. 3, pp. 402–406, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Shukla and S. Gupta, “Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells,” Cell Cycle, vol. 6, no. 9, pp. 1102–1114, 2007. View at Google Scholar · View at Scopus
  26. Z. P. Czuba and W. Krol, “The importance of hydroxyl substituent in position 4 in flavonoids for modulation of chemiluminescence generated by an enzymatic system (horseradish peroxidase-luminol-hydrogen peroxide),” Current Topics in Biophysics, vol. 20, pp. 38–41, 1996. View at Google Scholar
  27. K. Plochmann, G. Korte, E. Koutsilieri et al., “Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells,” Archives of Biochemistry and Biophysics, vol. 460, no. 1, pp. 1–9, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Horinaka, T. Yoshida, T. Shiraishi et al., “The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells,” Biochemical and Biophysical Research Communications, vol. 333, no. 3, pp. 833–838, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Yoshida, M. Konishi, M. Horinaka et al., “Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis,” Biochemical and Biophysical Research Communications, vol. 375, no. 1, pp. 129–133, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. W. Chen, X. Wang, J. Zhuang, L. Zhang, and Y. Lin, “Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells,” Carcinogenesis, vol. 28, no. 10, pp. 2114–2121, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. Y.-H. Kim, D.-H. Lee, J.-H. Jeong, Z. S. Guo, and Y. J. Lee, “Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway,” Biochemical Pharmacology, vol. 75, no. 10, pp. 1946–1958, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Taniguchi, T. Yoshida, M. Horinaka et al., “Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells,” Cancer Research, vol. 68, no. 21, pp. 8918–8927, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. E. Szliszka, Z. P. Czuba, K. Jernas, and W. Król, “Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),” International Journal of Molecular Sciences, vol. 9, no. 1, pp. 56–64, 2008. View at Publisher · View at Google Scholar · View at Scopus