Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

Table 2

Summary of anti-HCC herbal composite formula.

Herbal composite formula	Possible mechanisms of anti-HCC	References
Shi-Quan-Da-Bu-Tang (TJ-48)	Inhibits tumors growth, reduces oxidative DNA damage, inflammatory cell infiltration and cytokine expression	[76]
Sho-saiko-to (TJ-9)	Increases TNF-𝛼 and G-CSF; inhibits 8-OHdG formation; reduces the number of pre-neoplastic cells; cell-killing effect	[77–80]
Bu-Zhong-Yi-Qi-Tang	Stimulates productions of G-CSF and TNF-𝛼	[81]
Shenqi mixture (SQM)	Increases CD3^+, CD4^+, CD4^+/CD8^+, NK activity	[82]
Xiaoliu Pingyi Mixture (XLPY)	Inhibits growth; induces apoptosis; inhibits Bcl-2 gene	[83]
Sihoga-Yonggol-Moryo-Tang (SGYMT)	Inhibits MMP-2 and MMP-9; inhibits tumor invasion	[79]
QHF	Inhibits the growth of HCC	[84]
Fuzheng Jiedu Decoction (FJD)	Enhances PTEN; inhibits tumor invasion	[85]
Star-99	Inhibits the growth of HCC; induces apoptosis	[86]