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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 576962, 9 pages
http://dx.doi.org/10.1093/ecam/nep138
Original Article

Withania somnifera Improves Semen Quality in Stress-Related Male Fertility

1Department of Biochemistry, C.S.M. Medical University, Lucknow 26003, India
2Endrocrinology Division, Central Drug Research Institute, Lucknow 226001, India
3Department of Urology, C.S.M. Medical University, Lucknow 226003, India

Received 21 November 2008; Accepted 17 July 2009

Copyright © 2011 Abbas Ali Mahdi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. C. Sikka, “Relative impact of oxidative stress on male reproductive function,” Current Medicinal Chemistry, vol. 8, no. 7, pp. 851–862, 2001. View at Google Scholar · View at Scopus
  2. A. A. Mahdi, F. Bano, R. Singh, R. K. Singh, M. S. Siddiqui, and M. Hasan, “Seminal plasma superoxide dismutase and catalase activities in infertile men,” Journal of Medical Sciences Research, vol. 27, pp. 201–203, 1999. View at Google Scholar
  3. A. V. McGrady, “Effects of psychological stress on male reproduction: a review,” Archives of Andrology, vol. 13, no. 1, pp. 1–7, 1984. View at Google Scholar · View at Scopus
  4. S. C. Sikka and R. Wang, “Endocrine disruptors and estrogenic effects on male reproductive axis,” Asian Journal of Andrology, vol. 10, no. 1, pp. 134–145, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. K. K. Shukla, A. A. Mahdi, M. K. Ahmad, S. N. Shankhwar, S. Rajender, and S. P. Jaiswar, “Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis,” Fertility and Sterility, vol. 92, no. 6, pp. 1934–1940, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. M. P. Hardy, H.-B. Gao, Q. Dong et al., “Stress hormone and male reproductive function,” Cell and Tissue Research, vol. 322, no. 1, pp. 147–153, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Nagro-Vilar, “Stress and other environmental factors affecting fertility in men and women; overview,” Environmental Health Perspectives, vol. 101, pp. 59–64, 1993. View at Google Scholar
  8. P. J. Cowen, “Cortisol, serotonin and depression: all stressed out?” British Journal of Psychiatry, vol. 180, pp. 99–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. K. K. Shukla, A. A. Mahdi, S. N. Shankwar, and M. K. Ahmad, “Effect of Mucuna pruriens on hormonal status and semen quality in infertile males,” Contraception, vol. 78, p. 194, 2008. View at Google Scholar
  10. F. Bano, R. K. Singh, R. Singh, M. S. Siddiqui, and A. A. Mahdi, “Seminal plasma lipid peroxide levels in infertile men,” Journal of Endocrinology and Reproduction, vol. 3, pp. 20–28, 1999. View at Google Scholar
  11. C. H. Ramlau-Hansen, A. M. Thulstrup, A. S. Aggerholm, M. S. Jensen, G. Toft, and J. P. Bonde, “Is smoking a risk factor for decreased semen quality? A cross-sectional analysis,” Human Reproduction, vol. 22, no. 1, pp. 188–196, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. S. R. Soares and M. A. Melo, “Cigarette smoking and reproductive function,” Current Opinion in Obstetrics and Gynecology, vol. 20, no. 3, pp. 281–291, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. K. K. Shukla, A. A. Mahdi, M. K. Ahmad, S. N. Shankwar, S. P. Jaiswar, and S. C. Tiwari, “Mucuna pruriens reduces stress and improves the quality of semen in infertile males,” Evidence-Based Complementary and Alternative Medicine, vol. 7, no. 1, pp. 137–144, 2010. View at Publisher · View at Google Scholar
  14. M. K. Ahmad, A. A. Mahdi, K. K. Shukla, N. Islam, S. P. Jaiswar, and S. Ahmad, “Effect of Mucuna pruriens on semen profile and biochemical parameters in seminal plasma of infertile men,” Fertility and Sterility, vol. 90, no. 3, pp. 627–635, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. C. D. Spielberger, R. L. Gorsuch, and R. E. Lushene, STAI Manual for the State-Trait Anxiety Inventory, Consulting Psychologist Press, Palo Alto, Calif, USA, 1970.
  16. N. Oner and A. Le Comple, DurumLuluk-Surekilik Kaygi Envanteri: Ei Kitabi, Bogazici Universitesi Matbaasi, Istanbul, Turkey, 1998.
  17. World Health Organization, Laboratory Manual for The Examination oF Human Semen and Sperm Cervical Mucus Interaction, Cambridge University Press, New York, NY, USA, 4th edition, 1999.
  18. D. Singh, “Konch (Kiwach),” in Unani Dravvyagunadarsh, D. Singh, Ed., pp. 101–102, Jivan Shiksha Mudralay, Varanasi, India, 1974. View at Google Scholar
  19. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Google Scholar · View at Scopus
  20. J. M. McCord and I. Fridovich, “Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein),” Journal of Biological Chemistry, vol. 244, no. 22, pp. 6049–6055, 1969. View at Google Scholar · View at Scopus
  21. H. Aebi, “Catalase,” in Methods of Enzymatic Analysis, H. U. Bergmeyer, Ed., pp. 673–684, Academic Press, New York, NY, USA, 1974. View at Google Scholar
  22. P. J. Hissin and R. Hilf, “A fluorometric method for determination of oxidized and reduced glutathione in tissues,” Analytical Biochemistry, vol. 74, no. 1, pp. 214–226, 1976. View at Google Scholar · View at Scopus
  23. M. Gavella, V. Lipovac, M. Vučić, and B. Ročić, “Evaluation of ascorbate and urate antioxidant capacity in human semen,” Andrologia, vol. 29, no. 1, pp. 29–35, 1997. View at Google Scholar · View at Scopus
  24. A. E. Omu, T. Fatinikun, N. Mannazhath, and S. Abraham, “Significance of simultaneous determination of serum and seminal plasma α-tocopherol and retinol in infertile men by high-performance liquid chromatography,” Andrologia, vol. 31, no. 6, pp. 347–354, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. A. R. Midgley, “Radioimmunoassay for human follicle-stimulating hormone,” Journal of Clinical Endocrinology and Metabolism, vol. 27, no. 2, pp. 295–299, 1967. View at Google Scholar · View at Scopus
  26. L. B. Foster and R. T. Dunn, “Single antibody technique for radioimmunoassay of cortisol in unextracted serum or plasma,” Clinical Chemistry, vol. 20, no. 3, pp. 365–368, 1974. View at Google Scholar · View at Scopus
  27. M. S. Bhat, G. Rao, K. D. Murthy, and P. G. Bhat, “Housing in pyramid counteracts neuroendocrine and oxidative stress caused by chronic restraint in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 1, pp. 35–42, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Sharma, S. Dhanukar, and S. M. Karandikar, “Effect of long term administration of the roots of Ashwaganda and Shatawari,” Drugs, vol. 23, pp. 133–139, 1985. View at Google Scholar
  29. M. S. Jensen, L. M. Mabeck, G. Toft, A. M. Thulstrup, and J. P. Bonde, “Lower sperm counts following prenatal tobacco exposure,” Human Reproduction, vol. 20, no. 9, pp. 2559–2566, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. I. Llayperuma, W. D. Ratnasooriya, and T. R. Weerasooria, “Effect of Withania somnifera root extract on the sexual behavior of male rats,” Asian Journal of Andrology, vol. 4, pp. 295–298, 2004. View at Google Scholar
  31. G. Merino, S. Carranza Lira, and J. C. Martínez-Chéquer, “Effects of cigarette smoking on semen characteristics of a population in Mexico,” Archives of Andrology, vol. 41, no. 1, pp. 11–15, 1998. View at Google Scholar · View at Scopus
  32. R. S. Sangwan, N. Das Chaurasiya, P. Lal et al., “Withanolide A biogeneration in in vitro shoot cultures of Ashwagandha (Withania somnifera Dunal), a main medicinal plant in ayurveda,” Chemical and Pharmaceutical Bulletin, vol. 55, no. 9, pp. 1371–1375, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Pook and W. Krause, “Stress reduction in male infertility patients: a randomized, controlled trial,” Fertility and Sterility, vol. 83, no. 1, pp. 68–73, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Sepaniak, T. Forges, H. Gerard, B. Foliguet, M.-C. Bene, and P. Monnier-Barbarino, “The influence of cigarette smoking on human sperm quality and DNA fragmentation,” Toxicology, vol. 223, no. 1-2, pp. 54–60, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. C. G. Smith, “Drug effects on male sexual function,” Clinical Obstetrics and Gynecology, vol. 25, no. 3, pp. 525–531, 1982. View at Google Scholar · View at Scopus
  36. L. Arambewela and R. Silva, Eds., Withania Somnifera, Ceylon Institute of Scientific and Industrial Research, Colombo, Sri Lanka, 1999.
  37. A. Agmo, R. G. Paredes, L. Sierra, and I. Garces, “The inhibitory effects on sexual behaviour and ambulatory activity of the mixed GA agonist proabide are differentially blocked by GABA receptor agonists,” Psychopharmacology, vol. 129, pp. 127–134, 1997. View at Google Scholar