Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Tab 1

Original Article

Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae)

Table 1

Return of function following crush injury to the peroneal nerve as shown by PFI.

GroupPFI values
Day 0Day 4Day 7Day 10Day 14Day 17

Negative control−15.63 ± 4.21 Unmeasurable due to dragging of operated foot−50.36 ± 7.13 −32.71 ± 5.27 −21.52 ± 8.88 [5]−18.88 ± 6.14 [5]
Aqueous extract −10.01 ± 3.40 −52.88 ± 12.34 −21.44 ± 5.56 −11.30 ± 4.49 −10.71 ± 2.43
(low dose)[8][2]
Aqueous extract−9.28 ± 2.74 −48.72 ± 9.72 −25.47 ± 6.42 −12.46 ± 6.28 −10.18 ± 4.11
(high dose)[6][4]
Mecobalamin−10.35 ± 1.80 −41.40 ± 5.11 −28.27 ± 7.21 −20.99 ± 7.05 −11.98 ± 1.66
[7][3]

PFI of rats treated with aqueous extracts of H. erinaceus fresh fruiting bodies or mecobalamin returned to pre-surgery values 4–7 days earlier than negative control. Values on day 0 are before surgery. Data are expressed as means ± standard deviation (n = 10 for day 0, 7 and 10 in all groups, day 4 in aqueous extract or mecobalamin group, day 14 in negative control group; n = 2, n = 4 and n = 3 for day 14 in low dose of aqueous extract, high dose of aqueous extract and mecobalamin group, respectively; n = 5 for day 17 in negative control group). Brackets indicate number of rats with PFI which had returned to pre-surgery values. Means with different letters in a same column are significantly different (P < .05, one-way ANOVA).

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