Evidence-Based Complementary and Alternative Medicine

Original Article

Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae)

Table 1

Return of function following crush injury to the peroneal nerve as shown by PFI.


Group	PFI values
Group	Day 0	Day 4	Day 7	Day 10	Day 14	Day 17

Negative control	−15.63 ± 4.21	Unmeasurable due to dragging of operated foot	−50.36 ± 7.13	−32.71 ± 5.27	−21.52 ± 8.88 [5]	−18.88 ± 6.14 [5]
Aqueous extract	−10.01 ± 3.40	−52.88 ± 12.34	−21.44 ± 5.56	−11.30 ± 4.49	−10.71 ± 2.43
(low dose)				[8]	[2]
Aqueous extract	−9.28 ± 2.74	−48.72 ± 9.72	−25.47 ± 6.42	−12.46 ± 6.28	−10.18 ± 4.11
(high dose)				[6]	[4]
Mecobalamin	−10.35 ± 1.80	−41.40 ± 5.11	−28.27 ± 7.21	−20.99 ± 7.05	−11.98 ± 1.66
				[7]	[3]

PFI of rats treated with aqueous extracts of H. erinaceus fresh fruiting bodies or mecobalamin returned to pre-surgery values 4–7 days earlier than negative control. Values on day 0 are before surgery. Data are expressed as means ± standard deviation (n = 10 for day 0, 7 and 10 in all groups, day 4 in aqueous extract or mecobalamin group, day 14 in negative control group; n = 2, n = 4 and n = 3 for day 14 in low dose of aqueous extract, high dose of aqueous extract and mecobalamin group, respectively; n = 5 for day 17 in negative control group). Brackets indicate number of rats with PFI which had returned to pre-surgery values. Means with different letters in a same column are significantly different (P < .05, one-way ANOVA).