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Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 606514, 9 pages
http://dx.doi.org/10.1155/2011/606514
Research Article

Acupuncture on the Endometrial Morphology, the Serum Estradiol and Progesterone Levels, and the Expression of Endometrial Leukaemia-inhibitor Factor and Osteopontin in Rats

1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430022, China
2Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430022, China
3Department of Gynecology, Endometriosis Research Center, Charité, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
4Institute of Pharmacy, Free University of Berlin, Koenigin Luise Strasse 2+4, 14195 Berlin, Germany
5Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430022, China

Received 2 February 2010; Revised 15 April 2010; Accepted 30 June 2010

Copyright © 2011 Houju Fu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although it is well known that acupuncture has beneficial effects on a variety of medical conditions especially in pain relief, nausea, and vomiting, it remains controversial whether it has positive impact on the female reproduction. The present study aimed to evaluate whether the following endometrial receptivity factors: the endometrial morphology, the hormone concentrations, and the protein expression of endometrial leukaemia-inhibitory factor (LIF) and osteopontin (OPN) could be improved by the acupuncture in clomiphene citrate(CC)-induced rat model during implantation period. Results showed that, compared with the CC group, glandular development advanced, the serum estradiol levels decreased significantly, and the glandular area and endometrial LIF and OPN expression were significantly higher in acupuncture group. There were no significant differences in serum progesterone levels, endometrial thickness, and stromal area between groups. These results suggest that acupuncture can improve certain aspects of endometrial receptivity in CC-induced rat model during implantation period, which might result in endometrial state better to female reproduction.