Attenuated Combined Action of Cyclosporine A and Hyperlipidemia on Atherogenesis in Rabbits by Thymoquinone
Table 2
Aortic atherosclerotic changes and MDA and serum protein carbonyl levels in the five groups at 8 weeks.
Group I
Group II
Group III
Group IV
Group V
Control
CsA
Cholesterol
Cholesterol + CsA
Cholesterol + CsA + TQ
Atherosclerosis
0
0
45.08 ± 11.65*
38.25 ± 8.74*†
18.41 ± 2.38*‡§
(% of total intimal surface)
Intimal area (×103μm2)
7.58 ± 1.52
4.72 ± 0.752
32.38 ± 7.13*
58.48 ± 15.51*‡
14.82 ± 1.87*‡§
Medial area (×103μm2)
52.31 ± 9.71
58.113 ± 8.89
64.56 ± 10.88
88.32 ± 10.08*‡
82.42 ± 4.71‡
Intima/media ratio
0.15 ± 0.01
0.08 ± 0.02
0.52 ± 0.06*
0.65 ± 0.12*‡
0.18 ± 0.03*‡§
Aorta MDA (nmol mg−1)
0.25 ± 0.06
0.47 ± 0.26*
0.53 ± 0.32*
1.83 ± 0.68*†‡
0.30 ± 0.03†‡§
Serum protein carbonyl content
1.34 ± 0.25
7.88 ± 1.88*
5.34 ± 1.36*
15.37 ± 1.29*†‡
9.50 ± 1.74*†‡§
(nmol ml−1)
Results are expressed as mean ± SD. Intimal and medial surface areas are expressed as ×103μm2.
*
P < .05, Group I versus other groups. †P < .05, Group II versus Groups III, IV and V. ‡P < .05, Group III versus Groups IV and V. §P < .05, Group IV versus Group V.
