Chemical Composition and, Cellular Evaluation of the Antioxidant Activity of Desmodium adscendens Leaves
Figure 6
Role of D. adcendens in prevention of diseases caused by free radicals. Generation of ROS is initiated by respiratory burst, which is set off by various physiological and environmental factors. The fabrication of an assortment of ROS from the molecular carried by different enzymes such as MPO (myloperoxidase), NADPH oxidase, and SOD (superoxide dismutase), leads to diverse cellular phenomena, namely, damage of DNA-repair proteins and caspases, lipid peroxydation, and DNA damage followed by mutation and NF-B activation. All these phenomena give rise to wide range of diseases. D. adscendens leaves extract inhibits the generations of the free radicals by scavenging both the mother and the daughter products and also by inducing the increase of SOD, CAT, GST, and GSH, resulting in the obstruction of various disease formation.
