3,4-Di-O-Caffeoylquinic Acid Inhibits Angiotensin-II-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Downregulating the JNK and PI3K/Akt Signaling Pathways
Figure 4
Ang-II induced protein kinses phosphorylation,
proliferation and migration. (a) Concentration-dependent responsiveness
of Ang-II-induced phosphorylation of p38, ERK1/2, JNK and Akt. (b) Effects
of SB203580, PD98059, SP600125 and wortmannin on the Ang-II-induced rVSMC proliferation.
(c) Effects of SB203580, PD98059, SP600125 and wortmannin on the Ang-II-induced
rVSMC migration. and , significant
difference versus samples treated with Ang II alone. Each histogram represents the mean ± SE of
three separate experiments run in triplicate on three separate cultures.
