The Ethanol Extract of Fructus trichosanthis Promotes Fetal Hemoglobin Production via p38 MAPK Activation and ERK Inactivation in K562 Cells
The effect of FT-EtOH extract and HU (25 g mL−1) on HbF production of K562 cells. Dose-dependent HbF-inducing effects of FT-EtOH extract on K562 cells after 6 days of treatment, expressed in (a) percentage of HbF per total proteins and (b) percentage of HbF per THb. The HbF concentration of each group was quantified by commercial ELISA kit. The results are expressed as mean SD of three cultures. The data are representative of three separate experiments. *, significantly different from non-treated control group.
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