Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 672136, 8 pages
http://dx.doi.org/10.1155/2011/672136
Research Article

Safety Evaluation of Yukmijihwang-tang: Assessment of Acute and Subchronic Toxicity in Rats

1Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea
2Division of Toxicology, Korea Institute of Toxicology, Daejeon 305-323, Republic of Korea

Received 7 June 2010; Revised 19 October 2010; Accepted 30 November 2010

Copyright © 2011 Hyekyung Ha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. D. Park, Prescriptionology, Young Lim Press, Seoul, Korea, 2003.
  2. J. K. Lee, N. H. Lee, H. Ha et al., “Analysis of studies on Yukmijihwang-tang for establishment of evidence based medicine,” Korean Journal of Oriental Physiology & Pathology, vol. 23, no. 1, pp. 15–26, 2009. View at Google Scholar
  3. J. T. Lee, Research on Intake of Chinese Medicine by Korean, vol. 91, KFDA, Seoul, Korea, 2006.
  4. QF Information Consulting Co., “The Report of Competition Pattern and Investment Strategy on "Liu wei di huang pills”,” (2009–2012). 2010, 34.
  5. D. G. Kang, E. J. Sohn, M. K. Moon et al., “Yukmijihwang-tang ameliorates ischemia/reperfusion-induced renal injury in rats,” Journal of Ethnopharmacology, vol. 104, no. 1-2, pp. 47–53, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Rho, M. Kang, B. Choi et al., “Effects of Yukmijihwang-tang derivatives (YMJd), a memory enhancing herbal extract, on the gene-expression profile in the rat hippocampus,” Biological and Pharmaceutical Bulletin, vol. 28, no. 1, pp. 87–93, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. X. L. Wei, “Studies on learning and memory function-related genes in the hippocampus and the relationship between the cognitive enhancing effect of liuwei dihuang decoction (LW) and gene expression,” Sheng Li Ke Xue Jin Zhan, vol. 31, no. 3, pp. 227–230, 2000. View at Google Scholar
  8. Y. C. Wu, J. H. Hsu, I. M. Liu, S. S. Liou, H. C. Su, and J. T. Cheng, “Increase of insulin sensitivity in diabetic rats received Die-Huang-Wan, a herbal mixture used in Chinese traditional medicine,” Acta Pharmacologica Sinica, vol. 23, no. 12, pp. 1181–1187, 2002. View at Google Scholar · View at Scopus
  9. Organization for Economic Cooperation and Development (OECD), “Principles of Good Laboratory Practice (OECD #408),” 1997. View at Google Scholar
  10. Korea Food and Drug Administration (KFDA), “The Testing Guidelines for Safety Evaluation of Drugs (Notification no. 2005-60),” 2005. View at Google Scholar
  11. Korea Food and Drug Administration (KFDA), “Good Laboratory Practice Regulation for Non-Clinical Laboratory Studies (Notification no. 2005-79),” 2005. View at Google Scholar
  12. Charles River Laboratories, “Clinical Laboratory Parameters for Crl:CD(SD) Rats,” 2006. View at Google Scholar
  13. F. Firenzuoli and L. Gori, “Herbal medicine today: clinical and research issues,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 1, pp. 37–40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. C. W. Cheng, Z. X. Bian, and T. X. Wu, “Systematic review of Chinese herbal medicine for functional constipation,” World Journal of Gastroenterology, vol. 15, no. 39, pp. 4886–4895, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. A. S. J. P. A. M. van Miert, “The use in animals of drugs licensed for human use only,” in Comparative Veterinary Pharmacology, Toxicology and Therapy, A. S. J. P. A. M. van Miert, M. G. Bogaert, and M. Debackere, Eds., pp. 489–500, MTP Press, Boston, Mass, USA, 1986. View at Google Scholar