Safety Evaluation of Yukmijihwang-tang: Assessment of Acute and Subchronic Toxicity in Rats

Table 4

Absolute organ weights (g) of male and female rats on subchronic toxicity study.

	(a) Males				(b) Females
Parameter	Vehicle control	YMJ-500 mg	YMJ-1000 mg	YMJ-2000 mg	Vehicle control	YMJ-500 mg	YMJ-1000 mg	YMJ-2000 mg
Brain	2.08±0.03	2.15±0.03	2.10±0.04	2.07±0.03	1.95±0.03	1.90±0.02	1.88±0.02	1.91±0.02
Pituitary	0.013±0.001	0.012±0.001	0.012±0.001	0.013±0.001	0.017±0.001	0.014±0.001	0.015±0.001	0.016±0.001
Liver	13.85±0.73	14.45±0.58	14.08±0.72	13.85±0.79	7.35±0.23	6.95±0.30	6.99±0.32	7.62±0.21
Spleen	0.810±0.069	0.842±0.045	0.763±0.038	0.765±0.043	0.520±0.018	0.466±0.031	0.480±0.027	0.500±0.027
Adrenal gland	0.064±0.002	0.062±0.004	0.059±0.002	0.063±0.003	0.072±0.004	0.065±0.002	0.065±0.003	0.068±0.002
Kidneys	3.51±0.14	3.41±0.13	3.42±0.11	3.42±0.15	1.90±0.05	1.80±0.06	1.89±0.09	1.89±0.26
Heart	1.58±0.05	1.56±0.06	1.55±0.04	1.55±0.07	0.98±0.02	0.93±0.04	0.89±0.03	0.95±0.03
Thymus	0.381±0.027	0.450±0.027	0.418±0.040	0.404±0.023	0.348±0.026	0.319±0.032	0.314±0.027	0.324±0.024
Salivary glands	0.710±0.020	0.773±0.023	0.701±0.021	0.732±0.037	0.426±0.011	0.429±0.018	0.436±0.023	0.425±0.015
Lung	1.57±0.04	1.67±0.05	1.60±0.05	1.59±0.09	1.20±0.02	1.19±0.04	1.14±0.03	1.23±0.04
Thyroid/Parathyriod	0.025±0.002	0.024±0.002	0.025±0.002	0.023±0.002	0.015±0.002	0.014±0.001	0.015±0.001	0.014±0.001
Epididymides	1.52±0.03	1.45±0.04	1.48±0.06	1.50±0.04	—	—	—	—
Seminal vesicle	1.80±0.10	1.83±0.07	1.75±0.07	1.97±0.09	—	—	—	—
Prostate	0.726±0.039	0.692±0.036	0.705±0048	0.745±0.038	—	—	—	—
Testes	3.49±0.11	3.23±0.07	3.26±0.18	3.34±0.06	—	—	—	—
Ovaries	—	—	—	—	0.088±0.004	0.078±0.004	0.079±0.004	0.084±0.028
Uterus/Cervix	—	—	—	—	0.830±0.078	0.556±0.049^∗	0.847±0.083	0.638±0.097

Values are mean ± SEM for 10 rats in each group. *: significant differences from the vehicle control (0) group (𝑃<.05). **: significant differences from the vehicle control (0) group (𝑃<.01).