The Neuroprotective Effect of Methanol Extract of Gagamjungjihwan and Fructus Euodiae on Ischemia-Induced Neuronal and Cognitive Impairment in the Rat

Figure 1

Time to escape on the platform during acquisition trials of the Morris water maze test. Four trials per day over 6 days were performed for the acquisition test. Rats were treated with GJ (200 mg kg^-1, p.o., GJ + ISCH group, n = 5) and FE (200 mg kg^-1, p.o., FE + ISCH group, n = 5) for 2 weeks after induction of cerebral ischemia. The sham-operated control group (SHAM, n = 6) and ischemia group (SAL + ISCH, n = 6) were not given any drug for 2 weeks after induction of ischemia. Significance with Tukey's test following an one-way ANOVA is indicated as *P <  .05, **P < .001 (Sham-operated versus SAL + ISCH, SAL + ISCH versus GJ + ISCH and SAL + ISCH versus FE + ISCH). Vertical lines indicate S.E.M (N = 5-6).