Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae)

Table 3

Effects of subchronic treatment with HEPA on body weight, physiological variables, and weights (tissues (g) per 100 g of body weight) of liver, kidneys, epididymal adipose tissue (EAT), soleus and extensor digitorium longus (EDL) in alloxan-diabetic rats.

Metabolic Parameters	NC	DC	DT125	DT250	DTI
Body Weight (g)	224.8 ± 6.4	147.8 ± 6.3	156.9 ± 10.2	172.7 ± 5.3^∗	205.5 ± 4.5^∗
	(+10.8%)	(−9.5%)	(−7.3%)	(+8.2%)	(+22.5%)
Liquid Intake (mL/24 h)	28.3 ± 1.6	193.8 ± 7.5	140.1 ± 8.3^∗	128.6 ± 6.2^∗	90.3 ± 5.9^∗
Food Intake (g/24 h)	18.2 ± 1.8	35.6 ± 0.8	32.8 ± 1.2	30.1 ± 1.8	28.5 ± 1.2
Urinary Volume (mL/24 h)	6.7 ± 1.1	136.3 ± 1.8	78.5 ± 4.1^∗	93.1 ± 3.5^∗	60.3 ± 4.7^∗
Liver	4.85 ± 0.25	6.04 ± 0.20	5.37 ± 0.35	5.07 ± 0.17^∗	5.29 ± 0.21^∗
Kidneys	0.44 ± 0.02	0.76 ± 0.02	0.49 ± 0.03^a	0.47 ± 0.03^a	0.46 ± 0.01^a
EAT	0.87 ± 0.20	0.14 ± 0.01	0.19 ± 0.01^∗	0.95 ± 0.08^∗	0.79 ± 0.06^∗
Soleus	0.07 ± 0.00	0.05 ± 0.00	0.06 ± 0.00^#	0.07 ± 0.00^#	0.06 ± 0.00^#
EDL	0.06 ± 0.00	0.04 ± 0.00	0.05 ± 0.00^∗	0.06 ± 0.00^∗	0.05 ± 0.00^∗

Data represent the end of treatment (Day 16). NC: nondiabetic control (vehicle); DC: diabetic control (vehicle); DT125: diabetic treated with HEPA (125 mg/Kg); DT250: diabetic treated with HEPA (250 mg/Kg); DTI: diabetic treated with insulin. Values given are the mean ± S.E.M. (𝑛=6). One-way ANOVA with Tukey’s post hoc test. ^∗𝑃<.05; ^#𝑃<.01; ^a𝑃<.0001 versus DC. Percentage changes (figures in parenthesis) in body weight of all groups were in comparison with yours initial (Day 0—opening of treatment).