Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 713523, 5 pages
http://dx.doi.org/10.1155/2011/713523
Research Article

The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier

1Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, China
2The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China

Received 27 November 2010; Accepted 4 January 2011

Copyright © 2011 Peng-Fei Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. T. Bellamy, “P-glycoproteins and multidrug resistance,” Annual Review of Pharmacology and Toxicology, vol. 36, pp. 161–183, 1996. View at Google Scholar · View at Scopus
  2. R. Perez-Tomas, “Multidrug resistance: retrospect and prospects in anti-cancer drug treatment,” Current Medicinal Chemistry, vol. 13, no. 16, pp. 1859–1876, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Clarke, S. M. O'Mahony, J. F. Cryan, and T. G. Dinan, “Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?” Human Psychopharmacology, vol. 24, no. 3, pp. 217–223, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Y. Han, J. Y. Fan, Y. Horie et al., “Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion,” Pharmacology and Therapeutics, vol. 117, no. 2, pp. 280–295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. D. H. Kim, SU. J. Jeon, JI. W. Jung et al., “Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice,” European Journal of Pharmacology, vol. 574, no. 2-3, pp. 140–147, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Y. H. Lam, A. C. Y. Lo, X. Sun, H. W. Luo, S. K. Chung, and N. J. Sucher, “Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice,” Phytomedicine, vol. 10, no. 4, pp. 286–291, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. Z. Mei, F. Zhang, L. Tao et al., “Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro,” Neuroscience Letters, vol. 452, no. 2, pp. 90–95, 2009. View at Publisher · View at Google Scholar
  8. X. X. Li, Z. W. Zhou, and S. F. Zhou, “Role of P-glycoprotein in the transport of tanshinone I, one active triterpenoid from salvia miltiorrhiza,” Drug Metabolism Letters, vol. 2, no. 3, pp. 223–230, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. X. I. Y. Yu, S. G. Lin, Z. W. Zhou et al., “Role of P-Glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge,” Current Drug Metabolism, vol. 8, no. 4, pp. 325–340, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. X. I. Y. Yu, S. G. Lin, X. Chen et al., “Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier,” Current Drug Metabolism, vol. 8, no. 4, pp. 365–377, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Tsuji and I. Tamai, “Blood-brain barrier function of P-glycoprotein,” Advanced Drug Delivery Reviews, vol. 25, no. 2-3, pp. 287–298, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. M. F. Fromm, “Importance of P-glycoprotein at blood-tissue barriers,” Trends in Pharmacological Sciences, vol. 25, no. 8, pp. 423–429, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. A. H. Schinkel, “P-Glycoprotein, a gatekeeper in the blood-brain barrier,” Advanced Drug Delivery Reviews, vol. 36, no. 2-3, pp. 179–194, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Du and J. Zhang, “Protective effects of salvianolic acid A against impairment of memory induced by cerebral ischemia-reperfusion in mice,” Chinese Medical Journal, vol. 110, no. 1, pp. 65–68, 1997. View at Google Scholar · View at Scopus