KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats

<table>AGE accumulation. (A) Immunohistochemical localization of AGEs in lens from a normal Zucker lean rat (ZL), vehicle-treated ZDF rat (ZDF) and ZDF rat treated with KIOM-79 (KIOM-79). A strong AGE immunoreactivity was observed in the cytoplasm of LECs and lens fibers of vehicle-treated ZDF rats. In contrast, immunoreactivity in lenses of KIOM-79-treated ZDF rats was decreased. X400 magnification. (B) Quantitative analysis of AGE immunoreactive intensity. (C) Western blot analysis of AGEs. Values in the bar graphs represent means ± SE, <svg height="11.125" id="M49" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 47.575001 11.125" width="47.575001" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus vehicle-treated ZDF rats.</table>

Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats 