KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats

<table>Distribution of NF-<svg height="7.9499998" id="M63" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 8.7375002 7.9499998" width="8.7375002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>B in LECs detected by southwestern histochemistry. (a) Representative photomicrograph of lens from a normal Zucker lean rat (ZL), vehicle-treated ZDF rat (ZDF), and ZDF rat treated with KIOM-79 (KIOM-79). Positive signals (arrow) for activated NF-<svg height="7.9499998" id="M64" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 8.7375002 7.9499998" width="8.7375002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>B were mainly detected in nuclei of LECs of the vehicle-treated ZDF rat. X400 magnification. (b) Quantitative analysis of positive cells in LECs. Values in the bar graphs represent means ± SE, <svg height="11.125" id="M65" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 47.575001 11.125" width="47.575001" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus normal ZL rats, <sup>#</sup><svg height="11.375" id="M67" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 50.549999 11.375" width="50.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus vehicle-treated ZDF rats.</table>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats 