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Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 717921, 10 pages
http://dx.doi.org/10.1155/2011/717921
Research Article

KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats

Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM), 483 Exporo, Yuseong-gu, Daejeon 305-811, Republic of Korea

Received 18 September 2009; Revised 23 April 2010; Accepted 30 June 2010

Copyright © 2011 Junghyun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Z. Kyselova, M. Stefek, and V. Bauer, “Pharmacological prevention of diabetic cataract,” Journal of Diabetes and Its Complications, vol. 18, no. 2, pp. 129–140, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. K. V. Ramana, B. Friedrich, A. Bhatnagar, and S. K. Srivastava, “Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells,” FASEB Journal, vol. 17, no. 2, pp. 315–317, 2003. View at Google Scholar · View at Scopus
  3. K. R. Hightower, J. R. Reddan, J. P. McCready, and D. C. Dziedzic, “Lens epithelium: a primary target of UVB irradiation,” Experimental Eye Research, vol. 59, no. 5, pp. 557–564, 1994. View at Publisher · View at Google Scholar · View at Scopus
  4. W.-C. Li, J. R. Kuszak, K. Dunn et al., “Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals,” Journal of Cell Biology, vol. 130, no. 1, pp. 169–181, 1995. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Ahmed, “Advanced glycation endproducts—role in pathology of diabetic complications,” Diabetes Research and Clinical Practice, vol. 67, no. 1, pp. 3–21, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Kasper, C. Roehlecke, M. Witt et al., “Induction of apoptosis by glyoxal in human embryonic lung epithelial cell line L132,” American Journal of Respiratory Cell and Molecular Biology, vol. 23, no. 4, pp. 485–491, 2000. View at Google Scholar · View at Scopus
  7. U. Denis, M. Lecomte, C. Paget, D. Ruggiero, N. Wiernsperger, and M. Lagarde, “Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction,” Free Radical Biology and Medicine, vol. 33, no. 2, pp. 236–247, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Kaji, S. Amano, T. Usui et al., “Expression and function of receptors for advanced glycation end products in bovine corneal endothelial cells,” Investigative Ophthalmology and Visual Science, vol. 44, no. 2, pp. 521–528, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. S.-B. Hong, K.-W. Lee, J. T. Handa, and C.-K. Joo, “Effect of advanced glycation end products on lens epithelial cells in vitro,” Biochemical and Biophysical Research Communications, vol. 275, no. 1, pp. 53–59, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. E. J. Dudek, F. Shang, and A. Taylor, “H2O2-mediated oxidative stress activates NF-κB in lens epithelial cells,” Free Radical Biology and Medicine, vol. 31, no. 5, pp. 651–658, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. D. H. Lee, K. S. Cho, S.-G. Park, E. K. Kim, and C.-K. Joo, “Cellular death mediated by nuclear factor kappa B (NF-κB) translocation in cultured human lens epithelial cells after ultraviolet-B irradiation,” Journal of Cataract and Refractive Surgery, vol. 31, no. 3, pp. 614–619, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Romeo, W.-H. Liu, V. Asnaghi, T. S. Kern, and M. Lorenzi, “Activation of nuclear factor-κB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes,” Diabetes, vol. 51, no. 7, pp. 2241–2248, 2002. View at Google Scholar · View at Scopus
  13. R. A. Kowluru, P. Koppolu, S. Chakrabarti, and S. Chen, “Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants,” Free Radical Research, vol. 37, no. 11, pp. 1169–1180, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. L. J. Hofseth, A. I. Robles, M. G. Espey, and C. C. Harris, “Nitric oxide is a signaling molecule that regulates gene expression,” Methods in Enzymology, vol. 396, pp. 326–340, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Sumi and L. J. Ignarro, “Regulation of inducible nitric oxide synthase expression in advanced glycation end product-stimulated RAW 264.7 cells: the role of heme oxygenase-1 and endogenous nitric oxide,” Diabetes, vol. 53, no. 7, pp. 1841–1850, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. H.-Y. Yun, V. L. Dawson, and T. M. Dawson, “Nitric oxide in health and disease of the nervous system,” Molecular Psychiatry, vol. 2, no. 4, pp. 300–310, 1997. View at Google Scholar · View at Scopus
  17. C. Nathan and Q.-W. Xie, “Nitric oxide synthases: roles, tolls, and controls,” Cell, vol. 78, no. 6, pp. 915–918, 1994. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Becquet, Y. Courtois, and O. Goureau, “Nitric oxide in the eye: multifaceted roles and diverse outcomes,” Survey of Ophthalmology, vol. 42, no. 1, pp. 71–82, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. G. C. Y. Chiou, “Review: effects of nitric oxide on eye diseases and their treatment,” Journal of Ocular Pharmacology and Therapeutics, vol. 17, no. 2, pp. 189–198, 2001. View at Google Scholar · View at Scopus
  20. M. Inomata, M. Hayashi, S. Shumiya, S. Kawashima, and Y. Ito, “Involvement of inducible nitric oxide synthase in cataract formation in Shumiya cataract rat (SCR),” Current Eye Research, vol. 23, no. 4, pp. 307–311, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Ito, T. Nabekura, M. Takeda et al., “Nitric oxide participates in cataract development in selenite-treated rats,” Current Eye Research, vol. 22, no. 3, pp. 215–220, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. E. M. Olofsson, S. L. Marklund, and A. Behndig, “Glucose-induced cataract in CuZn-SOD null lenses: an effect of nitric oxide?” Free Radical Biology and Medicine, vol. 42, no. 7, pp. 1098–1105, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. J. Jeon, M. H. Li, K. Y. Lee et al., “KIOM-79 inhibits LPS-induced iNOS gene expression by blocking NF-κB/Rel and p38 kinase activation in murine macrophages,” Journal of Ethnopharmacology, vol. 108, no. 1, pp. 38–45, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. S. Kim, Y. M. Lee, C.-S. Kim, E. J. Sohn, D. S. Jang, and J. S. Kim, “Inhibitory effect of KIOM-79, a new herbal prescription, on AGEs formation and expressions of type IV collagen and TGF-β1 in STZ-induced diabetic rats,” Korean Journal of Pharmacognosy, vol. 37, no. 2, pp. 103–109, 2006. View at Google Scholar · View at Scopus
  25. C.-S. Kim, E. J. Sohn, Y. S. Kim et al., “Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats,” Journal of Ethnopharmacology, vol. 111, no. 2, pp. 240–247, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. K. A. Kang, K. H. Lee, S. Y. Kim, H. S. Kim, J. S. Kim, and J. W. Hyun, “Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1,” Biological and Pharmaceutical Bulletin, vol. 30, no. 5, pp. 852–858, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. E. J. Sohn, Y. S. Kim, C.-S. Kim, Y. M. Lee, and J. S. Kim, “KIOM-79 prevents apoptotic cell death and AGEs accumulation in retinas of diabetic db/db mice,” Journal of Ethnopharmacology, vol. 121, no. 1, pp. 171–174, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Ao, C. Kikuchi, T. Ono, and Y. Notsu, “Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract,” Investigative Ophthalmology and Visual Science, vol. 32, no. 12, pp. 3078–3083, 1991. View at Google Scholar · View at Scopus
  29. E. J. Sohn, C.-S. Kim, Y. S. Kim et al., “Effects of magnolol (5,5-diallyl-2,2-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats,” Life Sciences, vol. 80, no. 5, pp. 468–475, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. M. A. Herńndez-Presa, C. Gómez-Guerrero, and J. Egido, “In situ non-radioactive detection of nuclear factors in paraffin sections by Southwestern histochemistry,” Kidney International, vol. 55, no. 1, pp. 209–214, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. W.-C. Li and A. Spector, “Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract,” Free Radical Biology and Medicine, vol. 20, no. 3, pp. 301–311, 1996. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Shibata, S. Takeuchi, S. Yokota, K. Kakimoto, F. Yonemori, and K. Wakitani, “Effects of peroxisome proliferator-activated receptor-α and -γ agonist, JTT-501, on diabetic complications in Zucker diabetic fatty rats,” British Journal of Pharmacology, vol. 130, no. 3, pp. 495–504, 2000. View at Google Scholar · View at Scopus
  33. Y. S. Kim, J. Kim, C. S. Kim et al., “KIOM-79, an inhibitor of AGEs-protein cross-linking, prevents progression of nephropathy in Zucker diabetic fatty rats,” Evidence-Based Complementary and Alternative Medicine. In press.
  34. E. Meezan, E. M. Meezan, K. Jones, R. Moore, S. Barnes, and J. K. Prasain, “Contrasting effects of puerarin and daidzin on glucose homeostasis in mice,” Journal of Agricultural and Food Chemistry, vol. 53, no. 22, pp. 8760–8767, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Takii, T. Kometani, T. Nishimura, T. Nakae, S. Okada, and T. Fushiki, “Antidiabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice,” Biological and Pharmaceutical Bulletin, vol. 24, no. 5, pp. 484–487, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. W.-C. Chen, S. Hayakawa, T. Yamamoto, H.-C. Su, I.-M. Liu, and J.-T. Cheng, “Mediation of β-endorphin by the isoflavone puerarin to lower plasma glucose in streptozotocin-induced diabetic rats,” Planta Medica, vol. 70, no. 2, pp. 113–116, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. L. N. Hao, Y. Q. Ling, X. M. Luo et al., “Puerarin decreases lens epithelium cell apoptosis induced partly by peroxynitrite in diabetic rats,” Sheng Li Xue Bao, vol. 58, pp. 584–592, 2006. View at Google Scholar
  38. A. K.-W. Tse, C.-K. Wan, X.-L. Shen, M. Yang, and W.-F. Fong, “Honokiol inhibits TNF-α-stimulated NF-κB activation and NF-κB-regulated gene expression through suppression of IKK activation,” Biochemical Pharmacology, vol. 70, no. 10, pp. 1443–1457, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. H.-C. Ou, F.-P. Chou, T.-M. Lin, C.-H. Yang, and W. H.-H. Sheu, “Protective effects of honokiol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells,” Chemico-Biological Interactions, vol. 161, no. 1, pp. 1–13, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. C. S. Lee, Y. J. Kim, and E. S. Han, “Glycyrrhizin protection against 3-morpholinosydnonime-induced mitochondrial dysfunction and cell death in lung epithelial cells,” Life Sciences, vol. 80, no. 19, pp. 1759–1767, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. B. Brüne, A. von Knethen, and K. B. Sandau, “Nitric oxide and its role in apoptosis,” European Journal of Pharmacology, vol. 351, no. 3, pp. 261–272, 1998. View at Publisher · View at Google Scholar · View at Scopus
  42. C.-L. Kao, C.-K. Chou, D.-C. Tsai et al., “Nitric oxide levels in the aqueous humor in cataract patients,” Journal of Cataract and Refractive Surgery, vol. 28, no. 3, pp. 507–512, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. D.-C. Tsai, S.-H. Chiou, F.-L. Lee et al., “Possible involvement of nitric oxide in the progression of diabetic retinopathy,” Ophthalmologica, vol. 217, no. 5, pp. 342–346, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. N. Nagai, Y. Liu, T. Fukuhata, and Y. Ito, “Inhibitors of inducible nitric oxide synthase prevent damage to human lens epithelial cells induced by interferon-gamma and lipopolysaccharide,” Biological and Pharmaceutical Bulletin, vol. 29, no. 10, pp. 2077–2081, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. R. Schreck, K. Albermann, and P. A. Baeuerle, “Nuclear factor κβ: an oxidative stress-responsive transcription factor of eukaryotic cells (a review),” Free Radical Research Communications, vol. 17, no. 4, pp. 221–237, 1992. View at Google Scholar · View at Scopus
  46. P. A. Baeuerle and T. Henkel, “Function and activation of NF-κB in the immune system,” Annual Review of Immunology, vol. 12, pp. 141–179, 1994. View at Google Scholar · View at Scopus
  47. T. W.-M. Boileau, T. M. Bray, and J. A. Bomser, “Ultraviolet radiation modulates nuclear factor kappa B activation in human lens epithelial cells,” Journal of Biochemical and Molecular Toxicology, vol. 17, no. 2, pp. 108–113, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. S. D. Yan, A. M. Schmidt, G. M. Anderson et al., “Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins,” Journal of Biological Chemistry, vol. 269, no. 13, pp. 9889–9897, 1994. View at Google Scholar · View at Scopus
  49. R. Singh, A. Barden, T. Mori, and L. Beilin, “Advanced glycation end-products: a review,” Diabetologia, vol. 44, no. 2, pp. 129–146, 2001. View at Publisher · View at Google Scholar · View at Scopus
  50. H. Vlassara, R. Bucala, and L. Striker, “Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging,” Laboratory Investigation, vol. 70, no. 2, pp. 138–151, 1994. View at Google Scholar · View at Scopus
  51. M. Alves, V. C. Calegari, D. A. Cunha, M. J. A. Saad, L. A. Velloso, and E. M. Rocha, “Increased expression of advanced glycation end-products and their receptor, and activation of nuclear factor kappa-B in lacrimal glands of diabetic rats,” Diabetologia, vol. 48, no. 12, pp. 2675–2681, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. H. Zhang, X. Chen, X. Teng, C. Snead, and J. D. Catravas, “Molecular cloning and analysis of the rat inducible nitric oxide synthase gene promoter in aortic smooth muscle cells,” Biochemical Pharmacology, vol. 55, no. 11, pp. 1873–1880, 1998. View at Publisher · View at Google Scholar · View at Scopus
  53. C. J. Lowenstein, E. W. Alley, P. Raval et al., “Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide,” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 20, pp. 9730–9734, 1993. View at Publisher · View at Google Scholar · View at Scopus
  54. Q.-W. Xie, Y. Kashiwabara, and C. Nathan, “Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase,” Journal of Biological Chemistry, vol. 269, no. 7, pp. 4705–4708, 1994. View at Google Scholar · View at Scopus
  55. K.-F. Beck and R. B. Sterzel, “Cloning and sequencing of the proximal promoter of the rat iNOS gene: activation of NFκB is not sufficient for transcription of the iNOS gene in rat mesangial cells,” FEBS Letters, vol. 394, no. 3, pp. 263–267, 1996. View at Publisher · View at Google Scholar · View at Scopus
  56. M. E. de Vera, R. A. Shapiro, A. K. Nussler et al., “Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 3, pp. 1054–1059, 1996. View at Publisher · View at Google Scholar · View at Scopus