Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma

Figure 6

Effect of RN on the expression of ICAM-1 and HO-1 in lung tissue of OVA-induced rat model of asthma. Wistar rat lung tissue was obtained 24 hours after last Ova challenge. Immunohistochemistry was performed as described in materials and methods section. Expression of ICAM-1 and HO-1 in the lung tissues was scored as described in Section 2. Normal: rats sensitized with OVA and challenged with saline. Control: rats sensitized and challenged with OVA. DXM: OVA-sensitized and challenged rats treated with Dexamethasone (10 mg/kg). RN-1: OVA-sensitized and challenged rats treated with RN (0.25 g/kg/day). RN-2: OVA-sensitized and challenged rats treated with RN (0.5 g/kg/day). Data are expressed as mean±S.E.M., 𝑛=10 rats per group. ^▴▴▴𝑃<.01 versus Normal; ^∗∗∗𝑃<.01 versus Control.