Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High Fat/Cholesterol Diet, with Attention to Acute Toxicity
Figure 1
Effects of EtFSC/fenofibrate treatment on serum triglyceride and total cholesterol levels in mice fed with HFC for 8 days (a) or 15 days (b). EtFSC (1–5 g/kg/day, i.g.) or fenofibrate (0.1 g/kg/day, i.g.) treatment was performed for 7 days (from Day 1 to 7 or from Day 8 to 14). Normal and drug-untreated hypercholesterolemic animals received the vehicle (0.5% CMC 10 ml/kg/day, i.g.) only. Twenty-four hours after the last dosing, serum triglyceride and total cholesterol levels were determined. Values given are the mean ± SEM of 10 mice per group. *, ** and *** versus the normal group; †, †† and ††† versus the drug-untreated hypercholesterolemic group.
