Different Influences on Tacrolimus Pharmacokinetics by Coadministrations of Zhi Ke and Zhi Shi in Rats

Table 1

Pharmacokinetic parameters of tacrolimus in six rats given tacrolimus (1.5 mg/kg) alone and coadministered with 2 g/kg of Zhi Ke and Zhi Shi decoctions.

Parameter		Treatment
	Tacrolimus alone	Tacrolimus + Zhi Ke	Tacrolimus + Zhi Shi
𝑇max (min)	22.5±8.2	27.5±6.1	25.0±7.7
𝐶max (ng⋅mL^−1)	19.2±4.2^a	17.7±4.8	5.3±0.8^b; (−72.4%)
AUC0−480; (ng⋅min⋅mL^−1)	2485.4±964.2^a	2330.5±268.8^a	696.2±182.5^b; (−72.0%)
MRT (min)	144.3±15.2	147.6±9.1	127.0±29.9

𝑇_max: time to reach 𝐶_max.
𝐶_max: the peak blood concentration.
AUC₀₋₄₈₀: area under the blood concentration-time curve to 480 min.
MRT: mean residence time.
Data expressed as mean ± S.D. Means in a row without a common superscript differ, 𝑃<.05.