KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats
Figure 3
Renal histopathology and function. (a) PAS staining of glomeruli. ×400; (b) glomerular volume in each group. Urine volume (c), albuminuria (d) and creatinine clearance (CCR) (e). ZL, normal lean rat; ZF, ZDF rat; ZF + AG, ZDF rat treated with AG (50 mg/kg); ZF + KIOM-79, ZDF rat treated with KIOM-79 (50 mg/kg). All data were expressed as mean ± SD (-7). *** versus ZL; ##; # versus ZF group, respectively.
