KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats
Figure 6
Anti-apoptotic effect of KIOM-79 in the renal podocyte of ZF rats. (a) A representative photomicrograph of TUNEL-positive cells, synaptopodin, and WT-1 in the glomerulus. Renal cortex from rats was stained using specific antibodies for synaptopodin and WT-1, which are specific markers of podocytes. Quantitative analyses of apoptotic cells (b), positive areas of synaptopodin (c) and positive cells of WT-1 (d). *** versus ZL group; ** versus ZF group.
