KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats

Table 1

Body weight and kidney weight of experimental rats.

	ZL	ZF	ZF + AG	ZF + KIOM-79
Body weight (g)
Initial	202.0 ± 24.4	276.6 ± 20.3	278.4 ± 9.1	266.5 ± 18.4
Final	338.5 ± 40.5	433.2 ± 69.4***	421.4 ± 66.1	414.6 ± 45.0
Kidney (mg/100 g body weight)
Left	280.9 ± 2.7	341.1 ± 19.0***	343.7 ± 26.8	316.6 ± 17.1*
Right	302.6 ± 8.2	348.5 ± 25.9***	333.7 ± 26.2	320.1 ± 17.8*

ZL: normal lean rat; ZF: ZDF rat; ZF + AG: ZDF rat treated with AG (50 mg/kg); ZF + KIOM-79: ZDF rat treated with KIOM-79 (50 mg/kg). All data were expressed as mean ± SD.
*** 𝑃<.001 versus ZL group; *𝑃<.05 versus ZF group.