Table 3: Effect on liver and kidney function tests during oral toxicity studies of active principle (LH II) isolated from ethanolic extract of seeds in normal rabbits (1 month treatment).

ParameterHealthy controlTreated 5 times of effective doseTreated 10 times of effective doseTreated 15 times of effective dose

Serum Bilirubin (mg dL−1)0.45 0.020.44 0.030.44 0.020.44 0.02
SGPT (IU L−1)11.2 1.112.1 1.311.5 0.911.5 0.9
Serum ALP (U L−1)33.0 2.433.2 3.133.0 2.833.0 2.8
Serum protein (g dL−1)8.0 0.97.9 0.68.0 0.68.0 0.2
Blood urea (mg dL−1)15.0 1.315.0 1.715.9 1.515.4 1.8
Serum Creatinine (mg dL−1)1.3 0.11.4 0.31.4 0.11.4 0.2

Values are mean SEM for five animals in each group. No significant difference between control and treated groups.