Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult

Table 1

Effect of MS methanol extract on biochemical parameters during cerebral post-ischemic reperfusion (15-min BCAO and 24-h reperfusion).

Group	SOD (U mg^−1 protein)	T-SH (×10^-5 M mg^−1 protein)	GSH (nM mg^−1 protein)
Sham	102.01 ± 17.91	3.59 ± 0.27	5.51 ± 0.34
Control	65.90 ± 14.39**	2.34 ± 0.26*	2.20 ± 0.92**
EGb761 (80 mg kg^−1)	97.21 ± 10.52**	3.42 ± 0.20***	5.54 ± 0.51**
MS (100 mg kg^−1)	84.45 ± 9.61**	3.29 ± 0.35**	3.75 ± 0.61***
MS (200 mg kg^−1)	97.81 ± 12.71*	3.47 ± 0.25***	5.57 ± 0.46**

All data are expressed as mean ± SEM, n = 8. Sham and treatment groups are compared with control (vehicle pre-treated). *P< .001, **P< .01, ***P< .05. Statistical analysis was done by one-way ANOVA followed by Tukey’s Test.