Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats
Hypothetical scheme of middle cerebral artery occlusion-(MCAO-) induced focal cerebral ischemia. MCAO decreases the blood flow of ischemic area followed by inducing a release of transcription factor HIF-1 . HIF-1 translocates into the nucleus in activating genes of iNOS and TNF-. iNOS may contribute to enhance the inflammatory responses by elevating nitric oxide (NO). TNF-, it shows to be involved in apoptosis through the activation of downstream caspases-3, and subsequently induces cerebral infarction.