Epigenetics in Traditional Chinese Pharmacy: A Bioinformatic Study at Pharmacopoeia Scale

<table>Meridian distribution of mechanism-specific epigenetic TCMMs. In total, 1155 TCMMs have meridian annotation. Among them 452 are epigenetic. Note that unlike natures and flavors, a TCMM can possess more than one meridians. DNMT- and HDAC-interacting TCMMs are overrepresented in spleen (<i>P</i> = .047 and .039, resp.); HAT-interacting medicinals in pericardium and gall bladder (<i>P</i> = .034 and .046, resp.); HMT-interacting medicinals in pericardium and small intestine (<i>P</i> = .024 and .030, resp.); MBD-interacting medicinals in kidney and liver (<i>P</i> = .011 and .047, resp.); PcG-interacting medicinals in spleen and lung (<i>P</i> = .038 and .044, resp.); and DICER-interacting medicinals in pericardium (<i>P</i> = .031). The above overrepresentations are from <i>P</i> &lt; .05.</table>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Epigenetics in Traditional Chinese Pharmacy: A Bioinformatic Study at Pharmacopoeia Scale 