Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death
Table 5
Effect of CCl4 and AEPD on the activities of the antioxidant enzymes in liver tissue of the normal and experimental animals.
Animal Groups
Cu/Zn SOD
Mn SOD
CAT
GST
GR
GPx
Vehicle
75.12 ± 3.65
65.73 ± 3.33
47.05 ± 2.35
2.25 ± 0.21
11.17 ± 0.55
91.47 ± 4.62
AEPD
69.67 ± 3.41
59.25 ± 3.01
40.57 ± 2.02
2.12 ± 0.17
10.23 ± 0.41
87.39 ± 4.44
CCl4
26.54 ± 2.04
16.38 ± 0.95
15.27 ± 0.76
0.85 ± 0.09
3.18 ± 0.23
44.25 ± 2.25
AEPD + CCl4
54.62 ± 2.81
50.12 ± 2.55
35.23 ± 1.76
1.95 ± 0.15
9.41 ± 0.47
81.21 ± 4.12
CCl4 + AEPD
49.75 ± 2.51
45.56 ± 2.31
31.55 ± 1.62
1.75 ± 0.12
8.75 ± 0.49
76.91 ± 3.87
VitC + CCl4
60.35 ± 3.05
55.17 ± 2.78
38.39 ± 1.92
2.05 ± 0.14
10.51 ± 0.53
85.73 ± 4.33
Recovery
30.12 ± 1.52
20.43 ± 1.04
18.35 ± 0.95
0.91 ± 0.11
3.22 ± 0.18
48.31 ± 2.45
SOD—U mg−1 protein; CAT—μmol min−1 mg−1 protein; GST—μmol min−1 mg−1 protein; GR–nmol min−1 mg−1 protein and GPx—nmol min−1 mg−1 protein. Data are mean ± SD, for six animals per group and were analyzed by one-way ANOVA, with Student-Newman-Keuls post hoc tests. Differences were attributed at P < .05, and homogeneous subgroups share common superscripted letters.
