Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Fig 1

Original Article

Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells

Figure 1

Effect of ABE on cell viability and cell death in THP-1 cells. THP-1 cells were seeded at 2 × 105 cells ml−1 and were then treated with ABE at the indicated concentrations for 24 h. (a) Cell viability was determined by MTT assay. Each point represents the mean ± SD of three independent experiments. The significance was determined by Student's t-test ( versus vehicle control (0)). (b) DNA contents and (c) annexin-V+ cells were analyzed by flow cytometer. Percentages represents the sub-G0/G1 phase and annexin-V+ cells, respectively. The results shown are from one representative experiment of three experiments that exhibited similar patterns.

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