Zataria multiflora Boiss and Carvacrol Affect β2-Adrenoceptors of Guinea Pig Trachea
Figure 3
Isoprenaline EC50 obtained in the presence of three concentrations of aqueous-ethanolic extract from Z. multiflora (0.5 Zataria 0.05, 1 Zataria 0.1, and 2 μg/mL, Zataria 0.2), carvacrol (0.1 Carvacrol 0.01, 0.2 Carvacrol 0.02, and 0.4 μg/mL, Carvacrol 0.04), 10 nM propranolol (Propranolol), and saline (O) in nonincubated trachea (a) (group 1: ) and (b) incubated tissues with chlorpheniramine (group 2: ). Statistical comparison between saline and other solutions. NS: nonsignificant difference, **, ***. Statistical comparison between different concentrations of the extract and carvacrol +, +++. EC50 obtained in the presence of three concentrations of the extract in group 1 ( for low concentration and for two higher concentrations) and only high concentration of carvacrol () was higher than group 2. The comparison of EC50 obtained in the presence of extract, carvacrol, and propranolol with that of saline and the data between two groups was done using the paired -test. The comparison of the data of different concentrations of extract and carvacrol was performed using one-way analysis of variance (ANOVA) with Tukey-Kramer multiple post test.
