Evidence-Based Complementary and Alternative Medicine

Research Article

Effects of Vitamin D Plus Calcium Supplements on Pharmacokinetics of Isoflavones in Thai Postmenopausal Women

Table 3

Pharmacokinetic parameters of genistein after receiving three different regimens.


Pharmacokinetic parameters^†	Treatment regimens
Pharmacokinetic parameters^†	Single ISO	Single ISO +D₃-calcium^‡	Continuous D₃-calcium/single ISO

T_max (h)	4.58	7.64*	6.08
T_max (h)	(2.11)	(2.16)	(2.78)
C_max (ng/mL)	593.33	578.99	688.56
C_max (ng/mL)	(303.31)	(240.98)	(285.42)
t_1/2 (h)	8.31	7.44	8.86
t_1/2 (h)	(4.90)	(2.27)	(4.09)
AUC_0-32 (ng·h/mL)	5804.19	6574.74	7758.56
AUC_0-32 (ng·h/mL)	(2643.87)	(2625.30)	(5068.69)
AUC_0-∞ (ng·h/mL)	6787.62	7434.65	9091.58
AUC_0-∞ (ng·h/mL)	(2793.66)	(2748.42)	(5394.67)

Data represents mean (SD). ^†The parameters were derived from analysis of the individual concentration-time curve. ^‡Data from one subject was ruled out because isoflavone concentration was detected in plasma sample at baseline. Single ISO: a single dose of Flava soy; Single ISO + D₃-calcium: a single dose of Flava soy and Caltrate 600 + D; Continuous D₃-calcium/single ISO: 1 tablet of Caltrate 600 + D twice a day for 7 days, followed by a single dose of Flava soy on the 8th day. * versus Single ISO.