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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 908743, 8 pages
http://dx.doi.org/10.1093/ecam/nen086
Original Article

Jungle Honey Enhances Immune Function and Antitumor Activity

1Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Kyoto, Japan
2Origins Japan Co. Ltd, Nagano, Japan
3Takara Shuzo Co. Ltd, Kyoto, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan
4Center for Health and the Environment, University of California Davis, California, USA

Received 16 June 2008; Accepted 17 December 2008

Copyright © 2011 Miki Fukuda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [43 citations]

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  • Abdulmlik A. Ghashm, Nor H. Othman, Mohammed N. Khattak, Noorliza M. Ismail, and Rajan Saini, “Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines,” Bmc Complementary And Alternative Medicine, vol. 10, 2010. View at Publisher · View at Google Scholar
  • V. Majtan, “Is manuka honey the best type of honey for wound care?,” Journal of Hospital Infection, vol. 74, no. 3, pp. 305–306, 2010. View at Publisher · View at Google Scholar
  • Agustine Nengsih Fauzi, Mohd. Nor Norazmi, and Nik Soriani Yaacob, “Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines,” Food and Chemical Toxicology, vol. 49, no. 4, pp. 871–878, 2011. View at Publisher · View at Google Scholar
  • João Paulo B. de Sousa, Mateus F. Leite, Renata F. Jorge, Dimas O. Resende, Ademar A. da Silva Filho, Niege A. J. C. Furtado, Ademilson E. E. Soares, Augusto C. C. Spadaro, Pedro Melillo de Magalhães, and Jairo K. Bastos, “Seasonality Role on the Phenolics from Cultivated Baccharis dracunculifolia,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, pp. 1–8, 2011. View at Publisher · View at Google Scholar
  • Majid Reza Farrokhi, Mohammad Vasei, Saeed Fareghbal, and Atefeh Bakhtazad, “Effect of Honey on Peridural Fibrosis Formation after Laminectomy in Rats: A Novel Experimental Study,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, pp. 1–6, 2011. View at Publisher · View at Google Scholar
  • Nor Hayati Othman, “Honey and Cancer: Sustainable Inverse Relationship Particularly for Developing Nations—A Review,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, pp. 1–10, 2012. View at Publisher · View at Google Scholar
  • Omotayo O. Erejuwa, Siti A. Sulaiman, and Mohd S. Ab Wahab, “Honey - A Novel Antidiabetic Agent,” International Journal of Biological Sciences, vol. 8, no. 6, pp. 913–934, 2012. View at Publisher · View at Google Scholar
  • Zafar H. Israili, “Antimicrobial Properties of Honey,” American Journal of Therapeutics, pp. 1, 2013. View at Publisher · View at Google Scholar
  • Maria J. Fernandez-Cabezudo, Rkia El-Kharrag, Fawaz Torab, Ghada Bashir, Junu A. George, Hakam El-Taji, and Basel K. Al-Ramadi, “Intravenous Administration of Manuka Honey Inhibits Tumor Growth and Improves Host Survival When Used in Combination with Chemotherapy in a Melanoma Mouse Model,” Plos One, vol. 8, no. 2, 2013. View at Publisher · View at Google Scholar
  • Laid Boukraa, Saâd Aissat, and Hama Benbarek, “Importance of Botanical Origin of Honeys,” Honey in Traditional and Modern Medicine, vol. 20131139, pp. 59–112, 2013. View at Publisher · View at Google Scholar
  • Laid Boukraa, and Laïd Boukraâ, “Honey in Burn and Wound Management,” Honey in Traditional and Modern Medicine, vol. 20131139, pp. 125–158, 2013. View at Publisher · View at Google Scholar
  • Yukari Nakajima, Yuki Nakano, Sono Fuwano, Natsumi Hayashi, Yukiho Hiratoko, Ayaka Kinoshita, Megumi Miyahara, Tsuyoshi Mochizuki, Kasumi Nishino, Yusuke Tsuruhara, Yoshika Yokokawa, Terumi Iuchi, Yuka Kon, Kanae Mukai, Yukie Kitayama, Naoko Murakado, Mayumi Okuwa, and Toshio Nakatani, “Effects of Three Types of Japanese Honey on Full-Thickness Wound in Mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–11, 2013. View at Publisher · View at Google Scholar
  • Sarfraz Ahmed, “Honey as a Potential Natural Anticancer Agent: A Review of Its Mechanisms,” Evidence-Based Complementary and Alternative Medicine, 2013. View at Publisher · View at Google Scholar
  • José Alvarez-Suarez, Massimiliano Gasparrini, Tamara Forbes-Hernández, Luca Mazzoni, and Francesca Giampieri, “The Composition and Biological Activity of Honey: A Focus on Manuka Honey,” Foods, vol. 3, no. 3, pp. 420–432, 2014. View at Publisher · View at Google Scholar
  • Pongsathon Premratanachai, and Chanpen Chanchao, “Review of the anticancer activities of bee products,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, no. 5, pp. 337–344, 2014. View at Publisher · View at Google Scholar
  • Nik Soriani Yaacob, and Nur Faezah Ismail, “Comparison of cytotoxicity and genotoxicity of 4-hydroxytamoxifen in combination with Tualang honey in MCF-7 and MCF-10A cells,” Bmc Complementary and Alternative Medicine, vol. 14, 2014. View at Publisher · View at Google Scholar
  • Juraj Majtan, “Honey: An immunomodulator in wound healing,” Wound Repair and Regeneration, 2014. View at Publisher · View at Google Scholar
  • M. Ahmed Mesaik, Nida Dastagir, Nazim Uddin, Khalid Rehman, and M. Kamran Azim, “Characterization of Immunomodulatory Activities of Honey Glycoproteins and Glycopeptides,” Journal of Agricultural and Food Chemistry, pp. 141222141244000, 2014. View at Publisher · View at Google Scholar
  • Omur Gunaldi, Seyda Erdogan, Dogan Gucluhan Guclu, Bekir Tugcu, Ender Ofluoglu, Serhat Baydin, and Erhan Emel, “"Honey" can Prevent Epidural Fibrosis Development After Laminectomy: An Experimental Study,” Turkish Neurosurgery, vol. 24, no. 6, pp. 849–854, 2014. View at Publisher · View at Google Scholar
  • Fahmida Alam, Md. Asiful Islam, Siew Hua Gan, and Md. Ibrahim Khalil, “Honey: A Potential Therapeutic Agent for Managing Diabetic Wounds,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–16, 2014. View at Publisher · View at Google Scholar
  • Luqman Hakim, Ekram Alias, Suzana Makpol, Wan Zurinah Wan Ngah, Nor Azian Morad, and Yasmin Anum Mohd Yusof, “Gelam Honey and Ginger Potentiate the Anti Cancer Effect of 5-FU against HCT 116 Colorectal Cancer Cells,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 11, pp. 4651–4657, 2014. View at Publisher · View at Google Scholar
  • Donya Nikaein, Ali Reza Khosravi, Zahra Moosavi, Hojjatollah Shokri, Ahmad Erfanmanesh, Hassan Ghorbani-Choboghlo, and Hadi Bagheri, “Effect of honey as an immunomodulator against invasive aspergillosis in BALB/c mice,” Journal of Apicultural Research, vol. 53, no. 1, pp. 84–90, 2014. View at Publisher · View at Google Scholar
  • M.R. Islam, J.S. Islam, G.M. Zatzman, M.A.H. Mughal, and M. Safiur Rahman, “References and Bibliography,” The Greening of Pharmaceutical Engineering, pp. 713–772, 2015. View at Publisher · View at Google Scholar
  • Bruno Fonseca-Santos, Marcos Antonio Correa, and Marlus Chorilli, “Sustainability, natural and organic cosmetics: consumer, products, efficacy, toxicological and regulatory considerations,” Brazilian Journal Of Pharmaceutical Sciences, vol. 51, no. 1, pp. 17–26, 2015. View at Publisher · View at Google Scholar
  • Hojjat Sadeghi-Aliabadi, Jamal Hamzeh, and Mina Mirian, “Investigation of Astragalus honey and propolis extract's cytotoxic effect on two human cancer cell lines and their oncogen and proapoptotic gene expression profiles.,” Advanced biomedical research, vol. 4, pp. 42, 2015. View at Publisher · View at Google Scholar
  • Ming Zhu, Yang Ling, Qiufeng Qi, Yaping Zhang, Yanqing Bao, and Yongping Liu, “ The Immunomodulatory Effects of Nidus Vespae on Human Peripheral Blood Immune Cells In Vitro ,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–6, 2015. View at Publisher · View at Google Scholar
  • Laura Porcza, Claire Simms, and Mridula Chopra, “Honey and Cancer: Current Status and Future Directions,” Diseases, vol. 4, no. 4, pp. 30, 2016. View at Publisher · View at Google Scholar
  • Preethi G. Anantharaju, Prathima C. Gowda, Manjunatha G. Vimalambike, and SubbaRao V. Madhunapantula, “An overview on the role of dietary phenolics for the treatment of cancers,” Nutrition Journal, vol. 15, no. 1, 2016. View at Publisher · View at Google Scholar
  • Khan, and Islampp. 1–669, 2016. View at Publisher · View at Google Scholar
  • Reham F. El-Kased, “Natural antibacterial remedy for respiratory tract infections,” Asian Pacific Journal of Tropical Biomedicine, 2016. View at Publisher · View at Google Scholar
  • Ni Cheng, Yuan Wang, and Wei Cao, “The Protective Effect of Whole Honey and Phenolic Extract on Oxidative DNA Damage in Mice Lymphocytes Using Comet Assay,” Plant Foods for Human Nutrition, 2017. View at Publisher · View at Google Scholar
  • Mehmet Fatih Seyhan, Eren Yılmaz, Özlem Timirci-Kahraman, Neslihan Saygılı, Halil İbrahim Kısakesen, Allison Pınar Eronat, Ayşe Begüm Ceviz, Sema Bilgiç Gazioğlu, Hülya Yılmaz-Aydoğan, and Oğuz Öztürk, “Anatolian honey is not only sweet but can also protect from breast cancer: Elixir for women from artemis to present,” IUBMB Life, 2017. View at Publisher · View at Google Scholar
  • M.M. Khan, and M.R. Islam, “References and Bibliography,” Zero Waste Engineering, pp. 619–663, 2017. View at Publisher · View at Google Scholar
  • Misato Ota, Yasutaka Nagachi, Kan’ichiro Ishiuchi, Yoshiaki Tabuchi, Feng Xu, Ming-Ying Shang, Shao-Qing Cai, and Toshiaki Makino, “Comparison of the inducible effects of licorice products with or without heat-processing and pre-treatment with honey on granulocyte colony-stimulating factor secretion in cultured enterocytes,” Journal of Ethnopharmacology, 2017. View at Publisher · View at Google Scholar
  • Sami K. Saikaly, and Amor Khachemoune, “Honey and Wound Healing: An Update,” American Journal of Clinical Dermatology, 2017. View at Publisher · View at Google Scholar
  • Faheemmaqbool, Kamal Niaz, Mohammad Abdollahi, and Haji Bahadar, “Health benefits of manuka honey as an essential constituent for tissue regeneration,” Current Drug Metabolism, vol. 18, no. 10, pp. 881–892, 2017. View at Publisher · View at Google Scholar
  • Behjat Javadi, “Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine,” Nutrition and Cancer, pp. 1–28, 2018. View at Publisher · View at Google Scholar
  • Ioanna Farakla, Eleni Koui, Jessica Arditi, Ifigenia Papageorgiou, Anastasia Bartzeliotou, Georgios E. Papadopoulos, Aimilia Mantzou, Chrysanthi Papathanasiou, Maria Dracopoulou, Maria Papastamataki, Paraskevi Moutsatsou, Ioannis Papassotiriou, George P. Chrousos, and Evangelia Charmandari, “Effect of honey on glucose and insulin concentrations in obese girls,” European Journal of Clinical Investigation, pp. e13042, 2018. View at Publisher · View at Google Scholar
  • Oguz Eroglu, Turgut Deniz, Ucler Kisa, Faruk Metin Comu, Sedat Kaygusuz, and Orhan Murat Kocak, “The effect of different types of honey on healing infected wounds,” Journal of Wound Care, vol. 27, no. Sup10, pp. S18–S25, 2018. View at Publisher · View at Google Scholar
  • Sarfraz Ahmed, Siti Amrah Sulaiman, Atif Amin Baig, Muhammad Ibrahim, Sana Liaqat, Saira Fatima, Sadia Jabeen, Nighat Shamim, and Nor Hayati Othman, “Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action,” Oxidative Medicine and Cellular Longevity, vol. 2018, pp. 1–19, 2018. View at Publisher · View at Google Scholar
  • Wenchao Yang, Chuang Zhang, Charlie Li, Zachary Yong Huang, and Xiaoqing Miao, “Pathway of 5-hydroxymethyl-2-furaldehyde formation in honey,” Journal of Food Science and Technology, 2019. View at Publisher · View at Google Scholar
  • Misato Ota, Xin Xu, Masaaki Minami, Yoshiaki Tabuchi, Shao-Qing Cai, Toshiaki Makino, Kan'ichiro Ishiuchi, Yasutaka Nagachi, and Maho Yagi-Utsumi, “The immunostimulatory effects and chemical characteristics of heated honey,” Journal of Ethnopharmacology, vol. 228, pp. 11–17, 2019. View at Publisher · View at Google Scholar
  • Mohd Amin Marwan Mohamad, Muhammad Alif Mazlan, Muhammad Ibrahim, Afzan Mat Yusof, Shamsul Azlin Ahmad Shamsuddin, Nik Fakhuruddin Nik Hassan, Hussin Muhammad, and Muhammad Lokman Md. Isa, “The effect of Malaysian stingless bee, Trigona spp. honey in promoting proliferation of the undifferentiated stem cell,” Asia Pacific Journal of Molecular Biology and Biotechnology, pp. 10–19, 2019. View at Publisher · View at Google Scholar