Curdione Plays an Important Role in the Inhibitory Effect of Curcuma aromatica on CYP3A4 in Caco-2 Cells

Table 1

Relationship between CYP3A4 inhibitory activity and content in MeOH extract.

	IC50 (μg/ml)	Content (%)
MeOH extract	21 ± 1.8	—
Hexane fraction	14 ± 2.6 (11.3(a))	54.0
Curdion	3.9 ± 1.7 (2.4(a))	11.4
Curcumin	>11.1	1.2

(a)Theoritical value calculated from the content in MeOH extract hypothesizing that curdion is the only component responsible for the CYP3A4 inhibitory activity of C. aromatica when the IC₅₀ of MeOH extract is 21 μg/ml. Results are means ± SD from triplicate experiments.