San-Huang-Xie-Xin-Tang Prevents Rat Hearts from Ischemia/Reperfusion-Induced Apoptosis through eNOS and MAPK Pathways

Table 1

Effect of SHXT on the severity of arrhythmias induced by ischemia/reperfusion in anesthetized rats.

Groups (𝑛=8)	Total VEBs	Duration of VT (s)	Duration of VF (s)	VT (%)	VF (%)	Irreversible VF (%)	Mortality (%)	Scores
Sham	63 ± 6	0	0	0	0	0	0	1 ± 1
I/R + vehicle	781 ± 49**	67 ± 3**	23 ± 3**	100	83	17	53	5 ± 1**
I/R + SHXT (10 mg/kg, i.v.)	326 ± 54^‡	37 ± 8^+	10 ± 3^+	100	33	0	0	3 ± 1^‡
I/R + SHXT (30 mg/kg, i.v.)	166 ± 28^‡	19 ± 3^‡	3 ± 1^‡	67	33	0	0	2 ± 1^‡
I/R + SHXT (10 mg/kg, oral)	535 ± 35^+	42 ± 4^+	20 ± 5	100	83	0	33	4 ± 1
I/R + SHXT (30 mg/kg, oral)	210 ± 30^‡	21 ± 3^‡	6 ± 1^‡	67	33	0	0	2 ± 1^‡

Values are mean ± SEM. Evaluation of arrhythmias described in Methods section. VEB: ventricular ectopic beats; VT: ventricular tachycardia; VF: ventricular fibrillation; I/R: ischemia/reperfusion; SHXT: San-Huang-Xie-Xin-Tang. ANOVA followed by Dunnett’s test.
^∗∗𝑃<.01 versus sham group; ⁺𝑃<.05, ^‡𝑃<.01 versus vehicle-treated rats.