Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways
Table 1
Clinical data of AML patients and apoptosis rate induced in vitro by BJO.
Patient no.
Sex/Age
HB (g/L)
WBC (×109)
Platelet (×1012/L)
APL Cell (%) in BM
AML type
Apoptosis rate (%) (500 μg/mL)
1
F/22
44
57.8
1.23
67
M5
51.31
2
M/58
109
30.0
1.73
77.5
M5
38.98
3
M/65
98
283.3
3.80
86
M5
53.79
4
F/25
64
125.0
18.6
54
M5
38.04
5
F/55
116
255
3.20
91.5
M5
96.23
6
M/65
66
171.6
1.9
67
M5
45.09
7
M/50
128
247
3.3
68.5
M5
53.44
8
M/46
84
26.3
2.3
88.5
M5
75.92
9
M/45
46
1.7
1.23
50
M5
28.80
10
M/63
50
75.0
1.28
76.8
M5
90.04
11
M/63
64
42.9
1.8
52
M5
53.79
12
F/47
85
439.6
3.1
52
CML-M5
29.35
13
M/59
77
23.3
2.67
27.5
CML-M5
92.48
14
F/45
56
41.9
3.45
26.4
CML-M5
63.84
15
F/62
96
235.6
3.8
90.0
M2
64.26
Note: The patients’ leukemic cells were treated with or without BJO for 6 h. Percentage of cells in the subG1 phase was measured using FACS as described in Materials and Method.
