Research Article
Enhanced Antitumoral Activity of Extracts Derived from Cultured Udotea flabellum (Chlorophyta)
Table 2
Cytotoxicity (CC50) of U. flabellum extracts on normal cell line and selective index (SI) for each cancer cell line.
| | Time (Irradiance treatment) | CC50 MDCK Cells | SI | | SiHa | HeLa | Hep-2 | KB |
| | Time = 0 | 297.9±11.2 | | | | | | Day = 10 | | | | | | | A | |
10
|
6.5
|
19.4
|
13.7
| | B | |
6.4
|
7.0
|
14.5
|
9.3
| | C | |
28
|
5.3
|
17.1
|
8.8
| | D | |
21
|
4.3
|
8.2
|
9.6
| | Day = 20 | | | | | | | A | |
3.6
|
7.9
|
5.0
|
2.6
| | B | |
4.3
|
9.2
|
5.4
|
2.3
| | C | |
5.8
|
5.5
|
5.0
|
3.2
| | D | |
6.0
|
5.0
|
4.2
|
3.4
| | Day = 30 | | | | | | | A | |
1.0
|
1.0
|
5.4
|
5.0
| | B | |
0.5
|
6.7
|
4.3
|
4.0
| | C | |
0.6
|
0.9
|
5.7
|
4.2
| | D | |
0.7
|
0.8
|
4.0
|
3.3
|
|
|
CC50: mean concentration that killed 50% of cells; SI = ratio of cytotoxic to antiproliferative activity.
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