Original Article
Bioactive Markers Based Pharmacokinetic Evaluation of Extracts of a Traditional Medicinal Plant, Piper sarmentosum
Table 2
Pharmacokinetic parameters of pellitorine in rats (n = 6) following an oral dose (500 mg kg−1) of ethanol extract of fruit of P. sarmentosum.
| | Rat | 1 | 2 | 3 | 4 | 5 | 6 | Mean ± SD |
| | AUC0-∞ (ng h mL−1) | 1154.352 | 989.1177 | 1013.913 | 979.7302 | 978.4666 | 1107.007 | 1037.098 ± 75.10543 | | AUMC0-∞ | 29 997.640 | 25 654.080 | 26 668.00 | 25 454.990 | 25 399.670 | 28 650.570 | 26 970.830 ± 1927.431 | | MRT (h) | 25.987 | 25.937 | 26.302 | 25.982 | 25.959 | 25.881 | 26.008 ± 0.149 | | T 1/2 (h) | 21.397 | 17.617 | 17.290 | 19.045 | 17.087 | 19.436 | 18.645 ± 1.654 | | C
max (ng mL−1) | 33.880 | 33.420 | 36.310 | 34.710 | 34.870 | 35.460 | 34.775 ± 1.047 | | T
max (h) | 8.000 | 8.000 | 8.000 | 8.000 | 8.000 | 8.000 | 8.000 ± 0.000 | | K
el (h−1) | 0.033 | 0.039 | 0.040 | 0.036 | 0.046 | 0.037 | 0.038 ± 0.005 | | Cl | 0.065 | 0.085 | 0.0751 | 0.086 | 0.087 | 0.071 | 0.078 ± 0.008 | | VD | 1.993 | 2.158 | 1.877 | 2.355 | 2.135 | 1.972 | 2.082 ± 0.156 |
|
|
