Bioactive Markers Based Pharmacokinetic Evaluation of Extracts of a Traditional Medicinal Plant, Piper sarmentosum

Table 3

Pharmacokinetic parameter of sarmentine in rats following an oral dose (500 mg kg⁻¹) of ethanol extract of fruit of P. sarmentosum.

Rat	1	2	3	4	5	6	Mean ± SD
AUC0-∞ (ng h mL^−1)	5078.443	5304.598	4674.769	4684.233	4749.764	4900.847	4898.776 ± 251.1527
AUMC0-∞	55 489.980	60 942.670	55 318.870	51 450.740	51 587.150	52 239.930	54 504.890 ± 3634.530
MRT (h)	10.927	11.489	11.834	10.984	10.861	10.659	11.126 ± 0.443
T 1/2 (h)	10.380	11.873	13.183	7.668	9.714	9.023	10.307 ± 1.985
C max (ng mL^−1)	196.547	194.318	166.476	194.929	194.54	202.669	191.580 ± 12.691
T max (h)	6.000	6.000	6.000	6.000	6.000	6.000	6.000 ± 0.000
K el (h^−1)	0.089	0.078	0.070	0.121	0.095	0.103	0.093 ± 0.018
Cl	0.004	0.004	0.004	0.005	0.005	0.004	0.004 ± 0.000
VD	0.042	0.052	0.059	0.038	0.048	0.039	0.047 ± 0.008