Bioactive Markers Based Pharmacokinetic Evaluation of Extracts of a Traditional Medicinal Plant, Piper sarmentosum
Table 4
Cumulative excretion of pellitorine, sarmentine and sarmentosine in feces after oral dose of 500 mg kg−1 of ethanol extract of fruit of P. sarmentosum, and outcome of the extract on urine volume in experimental and control groups.
Excretion parameters
Rat 1
Rat 2
Rat 3
Mean
SD
Excretion of pellitorine
Cumulative amount in μg (0–72 h)
0.091
0.0564
0.0845
0.0773
0.0183
Percent of dose
0.001
0.001
0.001
0.001
0.000
Peak time (h)
48.000
48.000
48.000
48.000
0.000
Maximum excretion rate (μg h−1)
0.002
0.002
0.002
0.002
0.000
Excretion of sarmentine
Cumulative amount in μg (0–72 h)
1.2176
0.866
0.844
0.976
0.2093
Percent of dose
0.0041
0.0036
0.0035
0.0037
0.0003
Peak time (h)
24.000
24.000
24.000
24.000
0.000
Maximum excretion rate (μg h−1)
0.026
0.028
0.025
0.026
0.002
Excretion of sarmentosine
Cumulative amount in μg (0–72 h)
5.206
3.046
4.882
4.377
1.165
Percent of dose
1.117
0.653
1.047
0.939
0.249
Peak time (h)
24.000
24.000
24.000
24.000
0.000
Maximum excretion rate (μg h−1)
0.155
0.078
0.148
0.127
0.043
Urine volume in experimental group
Cumulative urinary volume in mL (0–24 h)
14.520
18.350
16.750
16.540
1.924
Maximum urine flow rate (mL h−1)
0.605
0.765
0.697
0.689
0.081
Control 1
Control 2
Control 3
Mean
SD
Urine volume in control group
Cumulative urinary volume in mL (0–24 h)
15.670
17.340
14.430
15.813
1.461
Maximum urine flow rate (mL h−1)
0.653
0.723
0.602
0.659
0.061
Each value represents the mean of three rats ± SD.
