Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells
Figure 12
The effects of EAS5 on the PML-RARα fusion protein and DNMT1 of NB4 cells. EAS5 dramatically decreased the protein levels of PML-RARα and DNMT1. The cells were treated with PBS or EAS5 (3.75–30 μg/mL) for 72 h and then harvested. Cell lysates were then prepared for western blot analysis. EAS5: active fraction of THL.
