The effect of cordycepin on morphological change and DNA fragmentation in MA-10 cells. MA-10 cells were treated without (a), or with 10 μM (b), 100 μM (c), 1 mM (d), 2 mM (e) and 5 mM (f) cordycepin for 24 h. Morphological changes of cells were examined under light microscopy (bar: 0.1 mm; arrow heads: membrane blebbed cells). Also, gel electrophoresis of a 1 kb DNA ladder marker (lane M) or DNA isolated from MA-10 cells that were cultured for 24 h in the presence of medium alone, 100 μ or 1 mM cordycepin (g). DNA was visualized by ethidium bromide staining and photographed under UV illumination. Experiments were performed three times with similar results (Con = control).
