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Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 985832, 9 pages
Research Article

Action of Coriandrum sativum L. Essential Oil upon Oral Candida albicans Biofilm Formation

1Department of Microbiology and Immunology, Dental School of Piracicaba, University of Campinas-UNICAMP, 13414-903 Piracicaba, SP, Brazil
2Research Center for Chemistry, Biology and Agriculture, University of Campinas-UNICAMP, P.O. Box 6171, 13083-970 Campinas, SP, Brazil

Received 10 February 2011; Accepted 17 March 2011

Copyright © 2011 V. F. Furletti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The efficacy of extracts and essential oils from Allium tuberosum, Coriandrum sativum, Cymbopogon martini, Cymbopogon winterianus, and Santolina chamaecyparissus was evaluated against Candida spp. isolates from the oral cavity of patients with periodontal disease. The most active oil was fractionated and tested against C. albicans biofilm formation. The oils were obtained by water-distillation and the extracts were prepared with macerated dried plant material. The Minimal Inhibitory Concentration—MIC was determined by the microdilution method. Chemical characterization of oil constituents was performed using Gas Chromatography and Mass Spectrometry (GC-MS). C. sativum activity oil upon cell and biofilm morphology was evaluated by Scanning Electron Microscopy (SEM). The best activities against planktonic Candida spp. were observed for the essential oil and the grouped F8–10 fractions from C. sativum. The crude oil also affected the biofilm formation in C. albicans causing a decrease in the biofilm growth. Chemical analysis of the F8–10 fractions detected as major active compounds, 2-hexen-1-ol, 3-hexen-1-ol and cyclodecane. Standards of these compounds tested grouped provided a stronger activity than the oil suggesting a synergistic action from the major oil constituents. The activity of C. sativum oil demonstrates its potential for a new natural antifungal formulation.