Genetic Association of NPY Gene Polymorphisms with Dampness-Phlegm Pattern in Korean Stroke Patients

Table 1

Demographic parameters of study subjects.

Characteristics	Normal	Non-dampness-phlegm	sig.^a	Dampness-phlegm	sig.^b
𝑁	498	401		198
Anthropometric characteristics
Sex (M/F)	215/283	226/175	< .0001	104/94	< .05
Age (year)	60.76±9.77	67.02±11.94	< .0001	64.7±12.81	< .0001
Smoking (none/stop/active)	241/214/43	216/81/104	< .0001	117/21/60	< .0001
Drinking (none/stop/active)	298/31/168	199/59/143	< .0001	114/14/69	NS
WHR	0.88±0.06	0.93±0.07	< .0001	0.93±0.05	< .0001
Waist circumference (cm)	83.61±8.38	84.61±9.79	NS	87.13±9.82	< .001
TOAST classification
LAA	—	64	ND	30	ND
CE	—	15		8
SVO	—	237		123
SOE	—	9		2
SUE	—	14		4
Medical history
Hypertension (Yes, %)	60 (12.07)	217 (54.94)	< .0001	120 (60.61)	< .0001
Blood parameter
GOP (U/mL)	27.56±19.97	27.31±22.5	NS	26.08±16.07	NS
GPT (U/mL)	26.04±20.26	25.6±24.29	NS	26.19±23.37	NS
Total cholesterol (mg/dL)	202.23±40.04	181.5±43.68	< .0001	192.83±43.95	< .01
Triglyceride (mg/dL)	139.88±69.80	149.86±95.72	NS	150.75±101.28	NS
HDL-cholesterol (mg/dL)	52.28±12.69	46.1±14.33	< .0001	44.57±12.44	< .0001
LDL-cholesterol (mg/dL)	121.19±36.70	109.42±36.75	< .0001	121.21±40.35	NS
Bloog sugar (mg/dL)	99.75±10.79	112.05±34.48	< .0001	109.81±29.53	< .0001

All results except sex, TOAST categories, smoking, drinking, and hypertension are expressed as mean ± SD for continuous variables. NS: not significant. ND: not done. WHR: waist hip ratio. TOAST: trial of ORG 10172 in acute stroke treatment. LAA: large-artery atherosclerosis. CE: cardioembolism. SVO: small-vessel occlusion. SOE: stroke of other etiology. SUE: stroke of undetermined etiology. GOP: glutamate oxaloacetate transaminase. GPT: glutamate pyruvate transaminase. sig.^a: 𝑃 value of normal versus non-dampness-phlegm using a Student’s 𝑡-test or Wilcoxon rank-sum test in continuous variables, chi-square test, or Fisher’s exact test in categorical variables. sig.^b: 𝑃 value of normal versus dampness-phlegm using a Student’s 𝑡-test or Wilcoxon rank sum test in continuous variables, chi-square test, or Fisher’s exact test in categorical variables. 𝑃 values with statistical significance were presented in bold.