Genetic Association of NPY Gene Polymorphisms with Dampness-Phlegm Pattern in Korean Stroke Patients
Table 3
Genotype distribution of NPY polymorphism of dampness-phlegm and non-dampness-phlegm.
Model
SNPs
Genotype
Normal
Non-dampness-phlegm
OR [95% CI]
sig.
Dampness-phlegm
OR [95% CI]
sig.
Allele
G-1484A
G
682 (68.75)
544 (68)
0.988
0.9145
294 (74.24)
0.748
0.0524
A
310 (31.25)
256 (32)
[0.787, 1.240]
102 (25.76)
[0.558, 1.003]
C-1471T
C
824 (82.90)
663 (83.29)
1.051
0.7314
323 (81.98)
0.931
0.6867
T
170 (17.10)
133 (16.71)
[0.791, 1.398]
71 (18.02)
[0.656, 1.320]
C-399T
C
666 (67.0)
535 (66.88)
1.007
0.9511
288 (72.73)
0.737
0.0378
T
328 (33.0)
265 (33.13)
[0.804, 1.261]
108 (27.27)
[0.552, 0.983]
A1201G
A
653 (65.83)
497 (62.13)
0.868
0.2099
272 (68.69)
0.879
0.3666
G
339 (34.17)
303 (37.88)
[0.696, 1.083]
124 (31.31)
[0.664, 1.163]
C5325T
C
682 (68.75)
534 (66.75)
0.851
0.1658
250 (63.13)
1.250
0.1131
T
310 (31.25)
266 (33.25)
[0.678, 1.069]
146 (36.87)
[0.948, 1.648]
†Do
G-1484A
GG
240 (48.39)
181 (45.25)
0.93
0.6363
110 (55.56)
0.697
0.0583
GA+AA
256 (51.61)
219 (54.75)
[0.688, 1.257]
88 (44.44)
[0.480, 1.013]
C-1471T
CC
338 (68.01)
276 (69.35)
1.058
0.7319
135 (68.53)
0.918
0.6762
CT+TT
159 (31.99)
122 (30.65)
[0.765, 1.465]
62 (31.47)
[0.614, 1.373]
C-399T
CC
232 (46.68)
176 (44)
0.953
0.7569
107 (54.04)
0.663
0.0315
CT+TT
265 (53.32)
224 (56)
[0.705, 1.29]
91 (45.96)
[0.456, 0.964]
A1201G
AA
225 (45.36)
158 (39.5)
0.821
0.2059
95 (47.98)
0.862
0.4357
AG+GG
271 (54.64)
242(60.5)
[0.605, 1.114]
103 (52.02)
[0.594, 1.252]
C5325T
CC
241 (48.59)
179 (44.75)
0.794
0.1335
76 (38.38)
1.557
0.0210
CT+TT
255 (51.41)
221 (55.25)
[0.587, 1.073]
122 (61.62)
[1.069, 2.269]
†R
G-1484A
GG+GA
442 (89.11)
363 (90.75)
1.148
0.5868
184 (92.93)
0.700
0.2961
AA
54(10.89)
37 (9.25)
[0.697, 1.89]
14 (7.07)
[0.359, 1.366]
C-1471T
CC+CT
486 (97.79)
387 (97.24)
1.077
0.8826
188 (95.43)
0.937
0.9019
TT
11 (2.21)
11 (2.76)
[0.404, 2.868]
9 (4.57)
[0.330, 2.656]
C-399T
CC+CT
434 (87.32)
359 (89.75)
1.157
0.5444
181 (91.41)
0.750
0.3579
TT
63 (12.68)
41 (10.25)
[0.722, 1.853]
17 (8.59)
[0.406, 1.385]
A1201G
AA+AG
428 (86.29)
339 (84.75)
0.869
0.518
177 (89.39)
0.830
0.5201
GG
68 (13.71)
61 (15.25)
[0.568, 1.33]
21 (10.61)
[0.469, 1.466]
C5325T
CC+CT
441 (88.91)
355 (88.75)
0.878
0.5966
174 (87.88)
0.907
0.7457
TT
55 (11.09)
45 (11.25)
[0.544, 1.419]
24(12.12)
[0.503, 1.636]
Data are presented as frequencies (percentages). ORs after adjustment for sex, age, drinking, and smoking with normal versus non-dampness-phlegm. ORs after adjustment for sex, age, drinking, and smoking with normal versus dampness-phlegm. sig.: value of normal versus non-dampness-phlegm using multiple logistic regression analysis. sig.: value of normal versus dampness-phlegm using multiple logistic regression analysis. †Do and R denote dominant and recessive models, respectively. CI: confidence interval. -values with statistical significance were presented in bold (<0.05).
