Antiproliferative and Proapoptotic Effects of Labisia pumila Ethanol Extract and Its Active Fraction in Human Melanoma HM3KO Cells
Figure 1
Representative images from morphological observation under phase contrast of an inverted microscope of SF2Lp-treated and -untreated HM3KO cells. HM3KO cells were treated with 7.59 μg/mL SF2Lp for 24 (b), 48 (c), and 72 (d) hours. A population of 72 hours DMSO-treated HM3KO cells, which served as negative control, showed less apoptotic cells (a). Red arrows showed nuclear condensation and cells shrinkage due to apoptosis which occurred actively at the beginning of the treatment and the presence of apoptotic bodies (black arrows) after 72 hours of treatment. Magnification: 400x.
