Table 2: Results from ANOVA F-tests for the potency treatment (main effect and interaction with experimental day) in four different regions of interest (ROI).

Texture analysis Main effects (P value) Interaction with exp. day (P value) parameter ROI 0–50% ROI 50–70% ROI 70–90% ROI 90–100% ROI 0–50% ROI 50–70% ROI 70–90% ROI 90–100% Cluster_prominence 0.6344 0.3447 <0.0001 0.0651 0.1557 0.0175 0.0085 0.0493 Cluster_shade 0.0038 0.0002 0.1552 0.1584 0.6700 0.9604 0.8339 0.9768 Correlation 0.6482 0.0938 <0.0001 0.0131 0.0258 <0.0001 0.0186 0.1024 Diagonal_moment 0.0021 <0.0001 0.1406 0.0764 0.4649 0.9091 0.8331 0.9135 Difference_energy 0.6773 0.0160 <0.0001 0.0131 0.0217 0.0001 0.0380 0.0419 Difference_entropy 0.8924 0.0461 <0.0001 0.0123 0.0186 <0.0001 0.0240 0.0570 Energy 0.7202 0.0170 <0.0001 0.0235 0.0292 0.0001 0.0330 0.0467 Entropy 0.9311 0.0578 <0.0001 0.0416 0.0207 <0.0001 0.0172 0.0351 Inertia 0.6508 0.0939 <0.0001 0.0145 0.0258 <0.0001 0.0186 0.1158 Inverse_diff moment 0.3531 0.0199 <0.0001 0.0069 0.0103 <0.0001 0.0379 0.0096 Kappa 0.3137 0.0339 <0.0001 0.0085 0.0120 <0.0001 0.0271 0.0083 Maximum_probability 0.4692 0.1979 0.0140 0.0653 0.1840 0.0091 0.3755 0.0246 Sum_energy 0.1270 0.0550 <0.0001 0.0008 0.0129 <0.0001 0.0603 0.0498 Sum_entropy 0.5550 0.1241 <0.0001 0.0026 0.0280 <0.0001 0.0289 0.0415 Sum_variance 0.6193 0.0926 <0.0001 0.0071 0.0260 <0.0001 0.0180 0.0487

Note. Results from ANOVA F-tests for the potency treatment (Stannum met. 30x versus water 30x, main effect and interaction with experimental day), analysing all 15 second-order variables of texture analysis in four different regions-of-interest (ROI, defined as circular segments in % radius). Results originate from a full 3-way ANOVA with the independent experimental parameters (1) experimental day {LBI: 1–7, BRAD: 8–15; n = 15}, (2) treatment {Stannum met. 30x or water 30x; n = 2}, and (3) internal treatment replicate {1–3; n = 3}. Each experimental parameter combination (statistical treatment cell) was assessed by 6 biocrystallogram replicates. Highly significant effects (P < 0.01) are shown in bold.