Research Article
Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin
Table 2
Inhibitory potencies of extracts of RYR products or pure lovastatin on the activities of different CYP450 enzymes in human liver microsomes.
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The data are the mean ± SEM for three to four separate preparations. *The specific inhibitors were furafylline for CYP1A2, ticlopidine for CYP2B6 and CYP2C19, sulfaphenazole for CYP2C9, quinidine for CYP2D6, and ketoconazole for CYP3A4. aP value < 0.05 compared to pure lovastatin; bP value > 0.05 compared to the specific inhibitor for each enzyme. |