Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin
Table 5
Pharmacokinetic parameters of lovastatin and lovastatin acid in healthy subjects after a single dose of one LipoCol Forte capsule alone or with coadministration of 600 mg of gemfibrozil twice daily. The data are the mean ± SD for 13 subjects.
LipoCol Forte
LipoCol Forte with gemfibrozil
LipoCol Forte
LipoCol Forte with gemfibrozil
Lovastatin
Lovastatin acid
(ng h/mL)
5.00 ± 3.29
4.25 ± 1.78
31.1 ± 16.5
65.5 ± 31.6*
(ng h/mL)
5.68 ± 3.48
5.04 ± 1.86
33.1 ± 18.2
69.7 ± 31.7*
(ng/mL)
1.53 ± 1.45
1.21 ± 0.67
6.79 ± 3.78
14.31 ± 7.43*
(h)
3.08 ± 1.17
3.00 ± 1.37
4.85 ± 1.14
3.73 ± 1.20
MRT (h)
4.87 ± 1.28
5.32 ± 1.68
6.19 ± 1.38
5.77 ± 1.87
(h)
2.12 ± 0.70
2.55 ± 1.13
1.94 ± 0.75
1.94 ± 0.70
CL/F (L/h)
1374.0 ± 782.6
1372.5 ± 763.8
218.4 ± 108.6
99.9 ± 48.4*
(L)
4000.5 ± 2599.0
4512.9 ± 1805.5
644.3 ± 586.2
277.6 ± 154.8*
versus the treatment of LipoCol Forte capsule alone.
