Understanding the Molecular Mechanism of Interventions in Treating Rheumatoid Arthritis Patients with Corresponding Traditional Chinese Medicine Patterns Based on Bioinformatics Approach

Figure 5

The PPI networks of functional relationships between cold pattern and hot pattern in RA. Diamonds represent seed node. Cycles represent neighbor nodes. All edges represent interactions. Left: Cold pattern network is in the left, and hot pattern is in the right. The middle part is the commonly shared network by both cold pattern and hot pattern and is the common network of RA. Blue colored nodes (between cold pattern or hot pattern and the common shared part) are the connection between TCM pattern related highly condensed networks and common sharing network, which were important for intersection between cold pattern and hot pattern. Right: Further extensive analysis for the intersection between cold and hot patterns in RA.