Efficacy and Safety of Human Placental Extract Solution on Fatigue: A Double-Blind, Randomized, Placebo-Controlled Study

Table 4

CIS score change.

	Group 1 (𝑁=100)	Group 2 (𝑁=99)	Placebo group (𝑁=95)	P value^1	P value^2
	Mean ± SD	Mean ± SD	Mean ± SD
Baseline (Visit 1)	92.54 ± 11.55	92.43 ± 10.85	91.84 ± 9.73	0.6495*	0.6899*
Visit 3	76.19 ± 12.96	71.49 ± 15.06	76.75 ± 14.60
Visit 4	67.75 ± 13.49	68.02 ± 15.16	74.73 ± 16.45
Baseline-Visit 3	−16.35 ± 14.38	−20.94 ± 16.09	−15.09 ± 15.27	0.5551*	0.0102*
P value	<0.0001^∫	<0.0001^∫	<0.0001^∫
Baseline-Visit 4	−24.79 ± 15.27	−24.41 ± 17.57	−17.12 ± 17.23	0.0012*	0.0039*
P value	<0.0001^∫	<0.0001^∫	<0.0001^∫

*Unpaired t-test, ∫Paired t-test, Visit 3 over the baseline = Visit 3, Baseline, Visit 4 over the baseline = Visit 4, Baseline, ¹Comparison of group 1 with the placebo group, ²Comparison of group 2 with the placebo group.